| Sunday 19th October 2025 The Isuzu FA Vase 1st Round |
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| West Allotment Celtic | 1-2 | Cheadle Town |
| Yarm & Eaglescliffe | 5-0 | Colne |
| Saturday 18th October 2025 The Isuzu FA Vase 1st Round |
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| Ashton Town | 1-0 | Darwen FC |
| Barnoldswick Town | 1-0 | AFC Liverpool |
| Burscough | 6-0 | Billingham Synthonia |
| Eccleshill United | 1-2 | Chadderton |
| Euxton Villa | 1-1 | Carlisle City |
| (Carlisle City won 4-3 on penalties) | ||
| Horbury Town | 1-1 | Charnock Richard |
| (Charnock Richard won 4-3 on penalties) | ||
| Irlam | 2-2 | Shildon |
| (Irlam won 5-4 on penalties) | ||
| Nelson | 3-0 | Harrogate Railway Athletic |
| Northallerton Town | 1-2 | South Liverpool |
| Penistone Church | 1-2 | Droylsden |
| Prestwich Heys | 9-1 | Maltby Main |
| Ramsbottom United | 3-0 | Jarrow FC |
| Runcorn Town | 1-3 | Fulwood Amateurs |
| Stafford Town | 3-3 | Nuneaton Town |
| (Nuneaton Town won 4-2 on penalties) | ||
| Wythenshawe | 2-2 | Holker Old Boys |
| (Holker Old Boys won 4-3 on penalties) | ||
| Saturday 18th October 2025 The Edward Case Cup 1st Round South |
||
| Ashville | 2-1 | Wolverhampton Casuals |
| Saturday 18th October 2025 Premier Division |
||
| Atherton LR | 0-1 | West Didsbury & Chorlton |
| FC Isle of Man | 2-2 | FC St Helens |
| Longridge Town | 2-1 | Glossop North End |
| Padiham | 4-0 | Litherland REMYCA |
| Pilkington | 1-3 | City of Liverpool |
| Stockport Town | 2-2 | Abbey Hey |
| Saturday 18th October 2025 First Division North |
||
| Bacup Borough | 4-0 | MSB Woolton |
| Daisy Hill | 2-2 | Maine Road |
| Garstang | 1-7 | Thornton Cleveleys |
| Maghull | 7-0 | Steeton |
| Squires Gate | 2-2 | Ashton Athletic |
| Saturday 18th October 2025 First Division South |
||
| Cammell Laird 1907 | 2-0 | Allscott Heath |
| Cheadle Heath Nomads | 1-2 | Eccleshall |
| Foley Meir | 1-1 | Stockport Georgians |
| Haughmond | 3-2 | Wolverhampton Sporting Community |
| Sandbach United | 1-0 | Barnton |
| Telford Town | 1-0 | Market Drayton Town |
| Mon 20th Oct 2025 Premier Division |
|||
| 19:45 | Stockport Town v City of Liverpool | ||
| First Division South | |||
| 19:45 | Cheadle Heath Nomads v New Mills | ||
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Tuesday 21st October 2025 Liverpool Senior Cup Preliminary Round |
| MSB Woolton v Bootle |
| Played at Bootle |
| Tuesday 21st October 2025 Premier Division |
| Abbey Hey v Prestwich Heys |
| Burscough v Euxton Villa |
| Chadderton v Padiham |
| Charnock Richard v AFC Liverpool |
| Irlam v Barnoldswick Town |
| Ramsbottom United v Glossop North End |
| Wythenshawe v FC St Helens |
| Tuesday 21st October 2025 First Division North |
| Steeton v Nelson |
| Tuesday 21st October 2025 First Division South |
| Allscott Heath v Wolverhampton Sporting Community |
| Cammell Laird 1907 v Barnton |
| Market Drayton Town v Haughmond |
| Runcorn Town v Ashville |
| Shawbury United v Stafford Town |
| Foley Meir v Alsager Town (20:00) |
| Wednesday 22nd October 2025 First Division North |
| Garstang v Ashton Town |
| Wednesday 22nd October 2025 First Division South |
| Eccleshall v Sandbach United |
| Saturday 25th October 2025 Premier Division |
| Barnoldswick Town v Pilkington |
| Chadderton v AFC Liverpool |
| City of Liverpool v FC Isle of Man |
| Euxton Villa v Cheadle Town |
| FC St Helens v Stockport Town |
| Glossop North End v Charnock Richard |
| Litherland REMYCA v Wythenshawe |
| Longridge Town v Irlam |
| Padiham v Prestwich Heys |
| Ramsbottom United v Abbey Hey |
| South Liverpool v Atherton LR |
| West Didsbury & Chorlton v Burscough |
| Saturday 25th October 2025 First Division North |
| AFC Blackpool v MSB Woolton |
| Ashton Athletic v Colne |
| Darwen FC v Garstang |
| Droylsden v Steeton |
| Fulwood Amateurs v Squires Gate |
| Holker Old Boys v Maine Road |
| Maghull v Bacup Borough |
| Nelson v Ashton Town |
| Thornton Cleveleys v Daisy Hill |
| Saturday 25th October 2025 First Division South |
| Ashville v Alsager Town |
| Barnton v Telford Town |
| Haughmond v Foley Meir |
| New Mills v Shawbury United |
| Runcorn Town v Wolverhampton Casuals |
| Sandbach United v Cheadle Heath Nomads |
| Stafford Town v Cammell Laird 1907 |
| Stockport Georgians v Market Drayton Town |
| Wolverhampton Sporting Community v Eccleshall |
| Premier Division | P | GD | Pts | |
| 1 | Padiham | 14 | 26 | 37 |
| 2 | West Didsbury & Chorlton | 16 | 16 | 34 |
| 3 | Ramsbottom United | 14 | 18 | 32 |
| 4 | Wythenshawe | 14 | 11 | 31 |
| 5 | Irlam | 14 | 13 | 28 |
| 6 | Burscough | 14 | 11 | 26 |
| 7 | Chadderton | 12 | 19 | 25 |
| 8 | Atherton LR | 15 | 12 | 24 |
| 9 | FC St Helens | 14 | 5 | 23 |
| 10 | South Liverpool | 15 | 0 | 23 |
| 11 | Stockport Town | 15 | 0 | 23 |
| 12 | Pilkington | 18 | -9 | 23 |
| 13 | Longridge Town | 15 | -2 | 21 |
| 14 | Cheadle Town | 13 | 4 | 20 |
| 15 | Prestwich Heys | 13 | 4 | 20 |
| 16 | Charnock Richard | 13 | 4 | 15 |
| 17 | Euxton Villa | 14 | -6 | 15 |
| 18 | Barnoldswick Town | 13 | -17 | 15 |
| 19 | Glossop North End | 17 | -16 | 14 |
| 20 | City of Liverpool | 13 | -11 | 12 |
| 21 | FC Isle of Man | 16 | -25 | 11 |
| 22 | Abbey Hey | 14 | -14 | 9 |
| 23 | AFC Liverpool | 13 | -14 | 7 |
| 24 | Litherland REMYCA | 17 | -29 | 4 |
| First Division North | P | GD | Pts | |
| 1 | Droylsden | 11 | 11 | 20 |
| 2 | Maghull | 10 | 11 | 19 |
| 3 | Holker Old Boys | 9 | 9 | 16 |
| 4 | Ashton Town | 9 | 0 | 16 |
| 5 | Bacup Borough | 10 | -2 | 16 |
| 6 | Nelson | 7 | -2 | 15 |
| 7 | Maine Road | 10 | 8 | 14 |
| 8 | Thornton Cleveleys | 9 | 6 | 14 |
| 9 | Darwen FC | 9 | 2 | 14 |
| 10 | Fulwood Amateurs | 9 | 1 | 12 |
| 11 | Squires Gate | 10 | -2 | 12 |
| 12 | Steeton | 10 | -6 | 12 |
| 13 | AFC Blackpool | 7 | 3 | 10 |
| 14 | MSB Woolton | 10 | -7 | 10 |
| 15 | Colne | 7 | -2 | 8 |
| 16 | Daisy Hill | 10 | -6 | 7 |
| 17 | Ashton Athletic | 9 | -10 | 7 |
| 18 | Garstang | 8 | -14 | 6 |
| First Division South | P | GD | Pts | |
| 1 | Runcorn Town | 12 | 26 | 29 |
| 2 | Stockport Georgians | 13 | 14 | 27 |
| 3 | Telford Town | 12 | 17 | 26 |
| 4 | Eccleshall | 11 | 8 | 23 |
| 5 | Barnton | 13 | 7 | 23 |
| 6 | Sandbach United | 11 | 9 | 22 |
| 7 | Stafford Town | 11 | 11 | 20 |
| 8 | Ashville | 11 | 5 | 17 |
| 9 | New Mills | 11 | 4 | 17 |
| 10 | Allscott Heath | 12 | 0 | 16 |
| 11 | Alsager Town | 12 | -3 | 14 |
| 12 | Shawbury United | 12 | -11 | 14 |
| 13 | Foley Meir | 12 | -4 | 13 |
| 14 | Cammell Laird 1907 | 11 | -5 | 12 |
| 15 | Wolverhampton Casuals | 11 | -6 | 11 |
| 16 | Cheadle Heath Nomads | 13 | -10 | 11 |
| 17 | Haughmond | 13 | -13 | 9 |
| 18 | Market Drayton Town | 13 | -14 | 9 |
| 19 | Wolverhampton Sporting Community | 12 | -35 | 3 |
Tables correct as at Sat 18th Oct 2025
