| Wednesday 15th October 2025 Premier Division |
||
| Litherland REMYCA | 1-2 | Chadderton |
| South Liverpool | 1-1 | Euxton Villa |
| Wednesday 15th October 2025 First Division North |
||
| Bacup Borough | 2-1 | Colne |
| Tuesday 14th October 2025 Liverpool Senior Cup Preliminary Round |
||
| Burscough | 3-1 | Ashton Town |
| Maghull | 2-4 | Warrington Rylands 1906 |
| Tuesday 14th October 2025 Premier Division |
||
| Atherton LR | 0-1 | Wythenshawe |
| Barnoldswick Town | 1-3 | Ramsbottom United |
| Charnock Richard | 0-1 | West Didsbury & Chorlton |
| FC St Helens | 2-2 | Irlam |
| Padiham | 4-0 | AFC Liverpool |
| Prestwich Heys | 2-0 | Pilkington |
| Tuesday 14th October 2025 First Division North |
||
| Squires Gate | 0-1 | Holker Old Boys |
| Tuesday 14th October 2025 First Division South |
||
| Alsager Town | 0-4 | Runcorn Town |
| Ashville | 3-0 | Cheadle Heath Nomads |
| Tuesday 14th October 2025 Cheshire Senior Cup 1st Round |
||
| 1874 Northwich | 0-3 | Cheadle Town |
| Monday 13th October 2025 Cheshire Senior Cup 1st Round |
||
| Stockport Town | 4-1 | Hyde United |
| Saturday 11th October 2025 The Macron Cup 2nd Round |
||
| AFC Blackpool | 3-0 | Barnoldswick Town |
| Atherton LR | 1-1 | Burscough |
| (Burscough won 5-3 on penalties) | ||
| Cammell Laird 1907 | 3-2 | Wolverhampton Casuals |
| City of Liverpool | 2-2 | Charnock Richard |
| (Charnock Richard won 3-1 on penalties) | ||
| Colne | 1-3 | Euxton Villa |
| Eccleshall | 1-3 | Telford Town |
| FC St Helens | 0-2 | MSB Woolton |
| Foley Meir | 0-5 | Sandbach United |
| Garstang | 2-3 | Thornton Cleveleys |
| Maine Road | 1-2 | Cheadle Town |
| New Mills | 0-1 | Chadderton |
| Padiham | 0-6 | Nelson |
| Ramsbottom United | 3-2 | Prestwich Heys |
| Runcorn Town | 1-0 | Allscott Heath |
| West Didsbury & Chorlton | 4-0 | Abbey Hey |
| Saturday 11th October 2025 Premier Division |
||
| Litherland REMYCA | 1-3 | FC Isle of Man |
| Longridge Town | 1-1 | South Liverpool |
| Pilkington | 2-0 | Glossop North End |
| Wythenshawe | 2-1 | Stockport Town |
| Saturday 11th October 2025 First Division North |
||
| Ashton Athletic | 4-0 | Bacup Borough |
| Ashton Town | 2-1 | Steeton |
| Daisy Hill | 3-2 | Darwen FC |
| Droylsden | 0-1 | Holker Old Boys |
| Squires Gate | 3-0 | Fulwood Amateurs |
| Saturday 11th October 2025 First Division South |
||
| Cheadle Heath Nomads | 3-2 | Shawbury United |
| Haughmond | 4-3 | Barnton |
| Market Drayton Town | 1-4 | Alsager Town |
| Stafford Town | 2-3 | Ashville |
| Stockport Georgians | 4-1 | Wolverhampton Sporting Community |
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Saturday 18th October 2025 The Isuzu FA Vase 1st Round |
| Ashton Town v Darwen FC |
| Barnoldswick Town v AFC Liverpool |
| Burscough v Billingham Synthonia |
| Eccleshill United v Chadderton |
| Euxton Villa v Carlisle City |
| Horbury Town v Charnock Richard |
| Irlam v Shildon |
| Nelson v Harrogate Railway Athletic |
| Northallerton Town v South Liverpool |
| Penistone Church v Droylsden |
| Prestwich Heys v Maltby Main |
| Ramsbottom United v Jarrow FC |
| Runcorn Town v Fulwood Amateurs |
| Stafford Town v Nuneaton Town |
| Wythenshawe v Holker Old Boys |
| Saturday 18th October 2025 The Edward Case Cup 1st Round South |
| Ashville v Wolverhampton Casuals |
| Saturday 18th October 2025 Premier Division |
| Atherton LR v West Didsbury & Chorlton |
| Longridge Town v Glossop North End |
| Padiham v Litherland REMYCA |
| Pilkington v City of Liverpool |
| Stockport Town v Abbey Hey |
| FC Isle of Man v FC St Helens (18:00) |
| Saturday 18th October 2025 First Division North |
| Bacup Borough v MSB Woolton |
| Daisy Hill v Maine Road |
| Garstang v Thornton Cleveleys |
| Maghull v Steeton |
| Squires Gate v Ashton Athletic |
| Saturday 18th October 2025 First Division South |
| Cammell Laird 1907 v Allscott Heath |
| Cheadle Heath Nomads v Eccleshall |
| Foley Meir v Stockport Georgians |
| Haughmond v Wolverhampton Sporting Community |
| Sandbach United v Barnton |
| Telford Town v Market Drayton Town |
| Sunday 19th October 2025 The Isuzu FA Vase 1st Round |
| West Allotment Celtic v Cheadle Town |
| Yarm & Eaglescliffe v Colne |
| Premier Division | P | GD | Pts | |
| 1 | Padiham | 13 | 22 | 34 |
| 2 | Ramsbottom United | 14 | 18 | 32 |
| 3 | West Didsbury & Chorlton | 15 | 15 | 31 |
| 4 | Wythenshawe | 14 | 11 | 31 |
| 5 | Irlam | 14 | 13 | 28 |
| 6 | Burscough | 14 | 11 | 26 |
| 7 | Chadderton | 12 | 19 | 25 |
| 8 | Atherton LR | 14 | 13 | 24 |
| 9 | FC St Helens | 14 | 5 | 23 |
| 10 | South Liverpool | 15 | 0 | 23 |
| 11 | Pilkington | 17 | -7 | 23 |
| 12 | Stockport Town | 14 | 0 | 22 |
| 13 | Cheadle Town | 13 | 4 | 20 |
| 14 | Prestwich Heys | 13 | 4 | 20 |
| 15 | Longridge Town | 14 | -3 | 18 |
| 16 | Charnock Richard | 13 | 4 | 15 |
| 17 | Euxton Villa | 14 | -6 | 15 |
| 18 | Barnoldswick Town | 13 | -17 | 15 |
| 19 | Glossop North End | 16 | -15 | 14 |
| 20 | FC Isle of Man | 16 | -25 | 11 |
| 21 | City of Liverpool | 12 | -13 | 9 |
| 22 | Abbey Hey | 13 | -14 | 8 |
| 23 | AFC Liverpool | 13 | -14 | 7 |
| 24 | Litherland REMYCA | 16 | -25 | 4 |
| First Division North | P | GD | Pts | |
| 1 | Droylsden | 11 | 11 | 20 |
| 2 | Holker Old Boys | 9 | 9 | 16 |
| 3 | Maghull | 9 | 4 | 16 |
| 4 | Ashton Town | 9 | 0 | 16 |
| 5 | Nelson | 7 | -2 | 15 |
| 6 | Darwen FC | 9 | 2 | 14 |
| 7 | Maine Road | 9 | 8 | 13 |
| 8 | Bacup Borough | 9 | -6 | 13 |
| 9 | Fulwood Amateurs | 9 | 1 | 12 |
| 10 | Steeton | 9 | 1 | 12 |
| 11 | Thornton Cleveleys | 8 | 0 | 11 |
| 12 | Squires Gate | 9 | -2 | 11 |
| 13 | AFC Blackpool | 7 | 3 | 10 |
| 14 | MSB Woolton | 9 | -3 | 10 |
| 15 | Colne | 7 | -2 | 8 |
| 16 | Daisy Hill | 9 | -6 | 6 |
| 17 | Garstang | 7 | -8 | 6 |
| 18 | Ashton Athletic | 8 | -10 | 6 |
| First Division South | P | GD | Pts | |
| 1 | Runcorn Town | 12 | 26 | 29 |
| 2 | Stockport Georgians | 12 | 14 | 26 |
| 3 | Telford Town | 11 | 16 | 23 |
| 4 | Barnton | 12 | 8 | 23 |
| 5 | Stafford Town | 11 | 11 | 20 |
| 6 | Eccleshall | 10 | 7 | 20 |
| 7 | Sandbach United | 10 | 8 | 19 |
| 8 | Ashville | 11 | 5 | 17 |
| 9 | New Mills | 11 | 4 | 17 |
| 10 | Allscott Heath | 11 | 2 | 16 |
| 11 | Alsager Town | 12 | -3 | 14 |
| 12 | Shawbury United | 12 | -11 | 14 |
| 13 | Foley Meir | 11 | -4 | 12 |
| 14 | Wolverhampton Casuals | 11 | -6 | 11 |
| 15 | Cheadle Heath Nomads | 12 | -9 | 11 |
| 16 | Cammell Laird 1907 | 10 | -7 | 9 |
| 17 | Market Drayton Town | 12 | -13 | 9 |
| 18 | Haughmond | 12 | -14 | 6 |
| 19 | Wolverhampton Sporting Community | 11 | -34 | 3 |
Tables correct as at Wed 15th Oct 2025
