Note. Venues and Kick off times are always difficult for pre-season games. Where none is known, the venue is assumed as the home team ground and the kick off. If kick off is unknown, it is displayed as 00:00. Please check these details with the home club before you travel to a particular game.
| Tuesday 24th June 2025 | |||||
| 19:30 | Longridge Town | 1-1 | Chorley | Inglewhite Road | |
| The Mayoral Cup - Chorley won 5-4 on penalties | |||||
| Thursday 26th June 2025 | |||||
| 19:00 | Feniscowles and Pleasington FC | 1-5 | Longridge Town | Feniscowles and Pleasington War Memorial Recreation Ground | |
| Friday 27th June 2025 | |||||
| 19:00 | Fulwood Amateurs | 3-0 | Kendal Town | Lightfoot Green Lane | |
| Saturday 28th June 2025 | |||||
| 14:30 | CPD Y Rhyl | 1-0 | Barnoldswick Town | Belle Vue | |
| 13:00 | FC Kirkby | 1-3 | Ashton Town | ||
| 15:00 | Squires Gate | 0-1 | Chorley | The Skiddle Community Stadium | |
| Childrens Charity Cup | |||||
| Tuesday 1st July 2025 | |||||
| 19:00 | Allscott Heath | 10-2 | Prees United | The Giant Stadium | |
| 19:45 | Burscough | 3-3 | Maghull | The Community Ground | |
| 19:45 | Chadderton | 1-1 | Avro | Emplas Commercial North Stadium | |
| 19:45 | Colne | 1-2 | Wythenshawe | Haffners Eats Stadium | |
| 19:45 | Egerton | 2-3 | Alsager Town | Mereheath Lane | |
| 19:45 | Euxton Villa | 1-0 | Chorley | Jim Fowler Memorial Ground | |
| 19:00 | Freckleton | 0-0 | AFC Blackpool | Hodgson Memorial Ground | |
| 19:45 | Glossop North End | 2-0 | Stockport Georgians | The Asgard Engineering Stadium | |
| 19:00 | Gobowen Celtic | 3-2 | Shawbury United | Rhewl Playing Field | |
| 19:45 | Nelson | 1-0 | Longridge Town | The Daisy Arena Little Wembley | |
| 19:45 | Prestwich Heys | 1-2 | Daisy Hill | Adie Moran Park | |
| 19:45 | Sandbach United | 5-0 | Ball Haye Green | Sandbach Community Football Centre | |
| 19:00 | South Liverpool | 2-1 | Cammell Laird 1907 | North Field | |
| 19:30 | Telford Town | 3-1 | Llansantffraid | Shrewsbury College 3G | |
| Wednesday 2nd July 2025 | |||||
| 19:30 | Altrincham Youth | 0-4 | Barnton | Partington Sports Village | |
| 19:45 | Darwen | 1-1 | Cheadle Town | The Anchor Ground | |
| 20:00 | Garstang | 1-2 | Atherton LR | The Riverside | |
| 19:30 | Maine Road | 2-3 | Denton Town | Wright Robinson College | |
| 19:00 | Marshalls | 0-3 | Runcorn Town | Heron Eccles Playing Fields | |
| 19:45 | Squires Gate | 1-4 | Pilkington | The Skiddle Community Stadium | |
| Thursday 3rd July 2025 | |||||
| 19:30 | Bilston Town | 0-1 | Haughmond | Queen Street Ground | |
| 19:45 | Burscough | 4-0 | Burscough Richmond | The Community Ground | |
| 20:00 | Chadderton | 0-1 | Stockport Georgians | Emplas Commercial North Stadium | |
| Friday 4th July 2025 | |||||
| 19:00 | FC Isle of Man | 2-3 | Isle of Man FA | The Bowl | |
| Saturday 5th July 2025 | |||||
| 15:00 | Abbey Hey | 5-0 | Maine Road | Wright Robinson College | |
| 15:00 | Alsager Town | 2-2 | Congleton Town | Wood Park | |
| 15:00 | Astley & Buckshawe United | 1-1 | Runcorn Town | Lostock Skip Hire Community Ground | |
| 00:00 | Atherton LR | 1-1 | Bury | Crilly Park | |
| 15:00 | Avro | 4-0 | Droylsden | Vestacare Stadium | |
| 15:00 | Barnoldswick Town | 9-3 | Stockport Georgians | Silentnight Stadium | |
| 00:00 | Broadheath Central | 0-2 | MSB Woolton | Balfour Road | |
| 14:00 | Brocton | 1-2 | Eccleshall | St Peters Academy Fenton ST4 2RR | |
| 15:00 | Burscough Richmond | 2-3 | AFC Blackpool | Richmond Park | |
| 15:00 | Chadderton | 3-1 | Trafford | Emplas Commercial North Stadium | |
| 15:00 | Chew Moor Brook | 2-1 | Charnock Richard | ||
| 14:00 | Colwyn Bay | 0-1 | Stockport Town | Llanelian Road | |
| 13:00 | CPD Y Rhyl | 0-0 | Ashton Town | Belle Vue | |
| 14:00 | Dalton United | 0-2 | Garstang | Railway Meadow | |
| 15:00 | Darwen | 4-3 | Irlam | The Anchor Ground | |
| 15:00 | Euxton Villa | 2-4 | Warrington Rylands | Jim Fowler Memorial Ground | |
| 13:00 | Fulwood Amateurs | 7-0 | Chipping | Longridge Town FC | |
| George Melling Tournament Semi-Final | |||||
| 15:00 | Glossop North End | 1-1 | New Mills | The Asgard Engineering Stadium | |
| 00:00 | Guilsfield | P-P | Haughmond | Community Sports Centre | |
| 15:00 | Holker Old Boys | 0-3 | Barrow | The Handmark Engineering Stadium | |
| 13:00 | Hyde United | 1-3 | Wythenshawe | Ewen Fields | |
| 14:00 | Knutsford | 1-2 | Barnton | Manchester Road | |
| 00:00 | Litherland Remyca | P-P | Widnes | TBC | |
| 16:00 | Longridge Town | 3-1 | Hurst Green | Longridge Town FC | |
| George Melling Tournament Semi-Final | |||||
| 15:00 | Maghull | 2-1 | Bootle | DT Hughes Community Stadium | |
| 15:00 | Market Drayton Town | 2-2 | AFC Bridgnorth | Greenfields Sports Ground | |
| Jason Francis Memorial Cup (4-3 on pens) | |||||
| 15:00 | Nelson | 1-2 | Ramsbottom United | The Daisy Arena Little Wembley | |
| 00:00 | Newtown | 1-2 | AFC Liverpool | Latham Park | |
| 12:15 | Pilkington | 1-1 | Ashville | PSD Stadium | |
| 15:00 | Prestwich Heys | 1-2 | Atherton Collieries | Adie Moran Park | |
| 15:00 | Rainhill Town | 2-5 | FC St Helens | ||
| 15:00 | Rossendale | 0-4 | Padiham | Marl Pits Sports Complex | |
| 15:00 | Route One Rovers | 0-0 | Daisy Hill | Myra Shay | |
| 15:00 | Sandbach United | 0-2 | Caernarfon Town | Sandbach Community Football Centre | |
| 16:00 | Shawbury United | 1-0 | AFC Wolverhampton City | Shrewsbury Sports Village 3G | |
| 15:00 | Squires Gate | 1-0 | Blackpool XI | The Skiddle Community Stadium | |
| 15:00 | Stafford Town | 2-3 | Lye Town | Evans Park | |
| 14:00 | Stockport Town | P-P | Colwyn Bay | (to be played at Colwyn Bay) | |
| 16:30 | Stretford Paddock | 0-2 | Ashton Athletic | ||
| 14:00 | Telford Town | 1-3 | Gornal Athletic | Scat Grass | |
| 15:00 | Thackley | 1-3 | South Liverpool | The Dennyfield | |
| 13:00 | Thornton Cleveleys | 4-1 | Whitley Bay | Gamble Road | |
| 13:00 | Tintwistle Athletic | 1-6 | Cheadle Town | West Drive Football Centre | |
| 15:00 | Vauxhall MotorsRes | P-P | Cammell Laird 1907 | Vauxhall Motors Sports & Social Club | |
| 12:00 | West Didsbury & Chorlton | 8-1 | Flixton | Hardy Farm Training Pitch | |
| Sunday 6th July 2025 | |||||
| 13:00 | Hurst Green | 2-3 | Chipping | Longridge Town FC | |
| George Melling Tournament 3rd Place Play-Off | |||||
| 16:00 | Longridge Town | 3-0 | Fullwood Amateurs | Longridge Town FC | |
| George Melling Tournament Final | |||||
| Monday 7th July 2025 | |||||
| 19:45 | Market Drayton Town | 0-1 | Nantwich Town | Greenfields Sports Ground | |
| Tuesday 8th July 2025 | |||||
| 19:45 | Abbey Hey | 3-5 | Hyde United | The Abbey Stadium | |
| 19:45 | AFC Blackpool | 1-2 | Padiham | Mechanics Ground | |
| 19:30 | Aintree Villa | 1-1 | AFC Liverpool | Aintree Racecourse | |
| 19:30 | Allscott Heath | 2-2 | Church Stretton Town | The Giant Stadium | |
| 19:30 | Alsager Town | 1-0 | Bollington Town | Wood Park | |
| 19:45 | Barnoldswick Town | 3-0 | Silsden | Silentnight Stadium | |
| 19:45 | Burscough | 2-1 | Lancaster City | The Community Ground | |
| 19:45 | Chadderton | 2-1 | Atherton Collieries | Emplas Commercial North Stadium | |
| 19:30 | Cheadle Heath Nomads | 4-2 | Cheadle Town | Ideal Building Systems Stadium | |
| 19:45 | Droylsden | 1-4 | Glossop North End | The Butchers Arms | |
| Tony Downes Memorial Trophy | |||||
| 19:30 | Eccleshall | 3-3 | Congleton Town | Stoke Signage Stadium | |
| 19:15 | Elton Vale | 1-5 | Ramsbottom United | ||
| 19:45 | Euxton Villa | 1-2 | Runcorn Linnets | Jim Fowler Memorial Ground | |
| 19:30 | Foley Meir | 1-1 | Kidsgrove Athletic | Trentham Foods Stadium | |
| 19:30 | Hurst Green | 1-1 | Nelson | San Smithy Ground | |
| 19:45 | Irlam | 2-3 | Mossley | The Silver St Stadium | |
| 20:00 | Llansantffraid | 2-3 | Shawbury United | Recreation Ground | |
| 19:30 | Longridge Town | 1-2 | Morecambe | Inglewhite Road | |
| 19:30 | Maghull | 1-1 | FC St Helens | DT Hughes Community Stadium | |
| 19:45 | New Mills | 0-2 | Bacup Borough | Church Lane | |
| 19:45 | Prestwich Heys | 6-3 | Thornton Cleveleys | Adie Moran Park | |
| 19:45 | Sandbach United | 3-0 | Sandbach UnitedRes | Sandbach Community Football Centre | |
| 19:30 | Shifnal Town | 3-0 | Telford Town | Wrekin College | |
| 19:30 | Squires Gate | 1-0 | Fleetwood Town XI | The Skiddle Community Stadium | |
| 20:00 | Stafford Town | 2-3 | Coleshill Town | Evans Park | |
| 19:45 | Steeton | 1-3 | Campion | Marley Stadium | |
| 19:45 | Stockport Georgians | 0-3 | 1874 Northwich | Cromley Road | |
| 19:30 | Vauxhall Motors | 2-0 | South Liverpool | The vanEupen Arena | |
| 18:45 | Whalley Range | 0-2 | West Didsbury & Chorlton | Kings Road | |
| 19:45 | Winstanley Warriors | 0-3 | Ashville | Little Lane | |
| 19:30 | Wolstanton United | 1-2 | Wolverhampton Casuals | Keele University | |
| Wednesday 9th July 2025 | |||||
| 19:45 | AFC Crewe | 1-1 | Garstang | Wood Park Stadium | |
| 19:45 | Daisy Hill | 2-2 | Radcliffe | The Ginge Power Stadium | |
| 19:00 | Dalton United | 0-4 | Holker Old Boys | Railway Meadow | |
| 19:30 | MSB Woolton | 2-1 | Runcorn Town | Simpsons Hub | |
| 18:45 | Penycae | 3-1 | Haughmond | The Riverside Arena | |
| Thursday 10th July 2025 | |||||
| 19:00 | Brocton | 4-0 | Market Drayton Town | Lilleshall | |
| 19:00 | Daten | 1-1 | Ashton Athletic | WA3 5SH Culcheth, Warrington | |
| 19:30 | Eccleshall | P-P | Hanley Town | Stoke Signage Stadium | |
| Friday 11th July 2025 | |||||
| 19:00 | FC Isle of Man | 2-1 | NFA Football | The Bowl | |
| 19:30 | Garstang | P-P | Radcliffe ‘B’ | The Riverside | |
| 19:00 | Tempest United | 1-1 | Daisy Hill | ||
| Saturday 12th July 2025 | |||||
| 15:00 | Abbey Hey | 2-3 | Tintwistle Athletic | The Abbey Stadium | |
| 15:00 | AFC Blackpool | 0-2 | Ramsbottom United | Mechanics Ground | |
| 15:00 | AFC Liverpool | P-P | Skelmersdale United | LCFA Sefton | |
| 14:00 | Airbus UK Broughton | 4-3 | Burscough | Hollingsworth Group Stadium | |
| 15:00 | Alsager Town | 0-3 | Winsford United | Wood Park | |
| 15:00 | Atherstone Town | 2-3 | Stafford Town | Sheepy Road | |
| 15:00 | Barnoldswick Town | 1-1 | Bootle | Silentnight Stadium | |
| 13:00 | Barnton | 3-2 | Atherton LR | The Creative Hut Stadium | |
| 13:00 | Cammell Laird 1907 | 2-5 | 1874 Northwich | The OWS Engineering Ltd Stadium | |
| 13:00 | Chadderton | 1-2 | Gresford Athletic | Emplas Commercial North Stadium | |
| 15:00 | Cheadle Heath Nomads | 0-0 | Wythenshawe Town | Ideal Building Systems Stadium | |
| 13:30 | Cheadle Town | 1-1 | Stalybridge Celtic | The Ground Up Solutions Stadium | |
| 15:00 | Colne | 1-0 | Langho | Haffners Eats Stadium | |
| 15:00 | Dawley Town | P-P | Shawbury United | Doseley Road Playing Fields | |
| 14:00 | FC Isle of Man | 0-3 | Brackley Town | Ballacloan Stadium, Ramsey | |
| 15:00 | Foley Meir | 0-3 | Newcastle Town | Trentham Foods Stadium | |
| 00:00 | Fulwood Amateurs | 1-4 | Warrington Rylands | Lightfoot Green Lane | |
| 00:00 | Garstang | 7-0 | Bury Grammer School Old Boys | The Riverside | |
| 14:00 | Knutsford | 2-1 | Sandbach United | Manchester Rd Knutsford | |
| 15:00 | Longridge Town | 0-4 | Bamber Bridge | Inglewhite Road | |
| 15:00 | Ludlow Town | 2-2 | Wolverhampton Casuals | Flowfit Stadium | |
| 15:00 | Maghull | 1-1 | South LiverpoolRes | DT Hughes Community Stadium | |
| 15:00 | Marshalls | 1-7 | Ashville | Heron Eccles | |
| 15:00 | Mossley | 0-0 | Droylsden | Seel Park | |
| 3-2 pens | |||||
| 14:15 | MSB Woolton | 5-1 | Ruthin Town | Simpsons Hub | |
| 13:00 | New Mills | 1-2 | Nelson | Church Lane | |
| 15:00 | Newcastle Blue Star | P-P | Irlam | Scotswood Stadium | |
| 14:00 | Old Altrinchamians | 5-6 | Wythenshawe | Crossford Bridge Sports Ground | |
| 14:00 | Padiham | P-P | Atherton Collieries | Ruby Civil Arena | |
| 15:00 | Penrith | 2-2 | Charnock Richard | Frenchfield Park | |
| 00:00 | Pilkington | 2-3 | Lower Breck | PSD Stadium | |
| 14:30 | Redgate Clayton | 1-2 | Eccleshall | Northwood Lane | |
| 14:30 | Rossendale | 4-1 | Ashton Athletic | ||
| 15:00 | Route One Rovers | 1-3 | Bacup Borough | Myra Shay | |
| 15:00 | Runcorn Town | 2-2 | FC St Helens | Viridor Community Stadium | |
| 15:00 | Squires Gate | 0-6 | Radcliffe | The Skiddle Community Stadium | |
| 15:00 | Steeton | 3-1 | Nostell Miners Welfare | Marley Stadium | |
| 15:00 | Stockport Georgians | 1-3 | Prestwich Heys | Cromley Road | |
| 14:00 | Stockport Town | 4-0 | Chadertonians | Stockport Sports Village | |
| 15:00 | Stockport Town | P-P | Darwen | Stockport Sports Village | |
| 15:00 | Telford Town | 0-3 | Stafford Rangers | DRM Aggregate Arena | |
| 14:00 | Thornton Cleveleys | 1-0 | Upper Mill | Gamble Road | |
| 15:00 | Vauxhall Motors Res | 0-1 | AFC Liverpool | ||
| 15:00 | West Didsbury & Chorlton | 1-1 | Maine Road | Brookburn Road (3-5 on )Pens | |
| Rob Turley Trophy | |||||
| 15:00 | Witton Albion | 2-1 | Litherland REMYCA | Wincham Park | |
| Monday 14th July 2025 | |||||
| 19:30 | Stockport Town | 7-0 | Denton Town | Stockport Sports Village | |
| 19:30 | Stockport Town | P-P | Accrington Stanley U21 | Stockport Sports Village | |
| Tuesday 15th July 2025 | |||||
| 19:45 | Abbey Hey | 3-2 | Glossop North End | The Abbey Stadium | |
| John Harvey Memorial Trophy | |||||
| 19:30 | AFC Knowsley | 0-4 | Burscough | Lord Derby Memorial Playing Field | |
| 19:30 | Allscott Heath | 2-2 | FC Nations | The Giant Stadium | |
| 19:45 | Alsager Town | 1-9 | Hanley Town | Wood Park | |
| 19:30 | Ashton Town | 10-4 | Hindsford | The Bartons Group Stadium | |
| Atherton Charity Cup | |||||
| 19:45 | Atherton Collieries | 1-1 | West Didsbury & Chorlton | The Kensite Stadium | |
| 19:45 | Atherton LR | 2-2 | Maine Road | Crilly Park | |
| 19:30 | Barnton | P-P | St Helens Town | The Creative Hut Stadium | |
| 19:00 | Blackpool Wren Rovers | 1-2 | FC St Helens | Brews Park | |
| 19:45 | Bury | 2-1 | Ashton Athletic | Gigg Lane | |
| 19:30 | Cammell Laird 1907 | 2-2 | Litherland Remyca | The OWS Engineering Ltd Stadium | |
| 19:45 | Chadderton | 2-2 | Bacup Borough | Emplas Commercial North Stadium | |
| 19:30 | Cheadle Heath Nomads | 1-4 | Wythenshawe | Ideal Building Systems Stadium | |
| 19:30 | Cheadle Town | 3-0 | Mossley | The Ground Up Solutions Stadium | |
| 19:45 | Colne | 0-0 | Hurst Green | Haffners Eats Stadium | |
| 19:45 | Droylsden | P-P | CPD Rhyl | The Butchers Arms | |
| 19:45 | Droylsden | 2-4 | 1874 Northwich | The Butchers Arms | |
| 19:00 | Ercall Colts | P-P | Wolverhampton Casuals | Hadley Learning Centre | |
| 19:00 | Flixton | 1-5 | New Mills | ||
| 19:30 | Foley Meir | 0-3 | Crewe Alexandra | Trentham Foods Stadium | |
| 20:15 | Fulwood Amateurs | 3-0 | Pause United | UCLAN Sports Arena | |
| 19:45 | Irlam | 2-2 | Trafford | The Silver St Stadium | |
| 19:30 | Kidsgrove Athletic | 1-1 | Abbey Hulton | Autonet Insurance Stadium | |
| 19:45 | Liversedge | 3-1 | Steeton | The Leading Edge Clayborn Ground | |
| 18:30 | Maghull | 0-5 | Warrington Town | DT Hughes Community Stadium | |
| 19:45 | Market Drayton Town | 1-0 | Port Vale Academy | Greenfields Sports Ground | |
| 19:30 | Nelson | 3-3 | Barnoldswick Town | The Daisy Arena Little Wembley | |
| 19:30 | OJM Birmingham | 2-4 | Telford Town | ||
| 19:45 | Padiham | 4-1 | Daisy Hill | Ruby Civil Arena | |
| 00:00 | Prees United | P-P | Barnton | Prees Recreation Club | |
| 19:45 | Prestwich Heys | 1-0 | FC United of Manchester | Adie Moran Park | |
| 18:45 | Rossendale | 0-3 | Charnock Richard | Marl Pits Sports Centre, BB4 7SN | |
| 19:30 | Runcorn Town | 4-1 | Witton Albion | Viridor Community Stadium | |
| 19:45 | Sandbach United | 1-0 | Pilkington | Sandbach Community Football Centre | |
| 19:30 | Shawbury United | 3-2 | Wrockardine Wood | London Road SCAT 3G | |
| 19:45 | Squires Gate | 3-2 | Galgate FC | The Skiddle Community Stadium | |
| 19:45 | Stalybridge Celtic | P-P | Darwen | Bower Fold | |
| 19:30 | Stockport Georgians | 2-1 | FC Halifax Town U19 | Cromley Road | |
| 19:45 | Stone Old Alleynians | 1-0 | Stafford Town | Roe Lane ST5 3PH | |
| 19:30 | Telford Town | 4-2 | Birmingham OJM | DRM Aggregate Arena | |
| Wednesday 16th July 2025 | |||||
| 20:00 | Darwen | 2-1 | Stalybridge Celtic | The Anchor Ground | |
| 19:30 | Eccleshall | 4-1 | Silverdale Athletic | Stoke Signage Stadium | |
| 19:45 | Helsby | 0-4 | Ashville | Helsby Community Sports Centre | |
| 19:00 | Little Lever SC | 3-0 | Atherton LR | Lytham Road | |
| Atherton Cup | |||||
| 19:30 | MSB Woolton | 2-0 | AFC Liverpool | Simpsons Hub | |
| 19:00 | Shifnal Town Development | 1-4 | Haughmond | Acoustafoam Stadium, TF11 8PD | |
| 19:30 | South Liverpool | 0-4 | Lower Breck | Jericho Lane | |
| Thursday 17th July 2025 | |||||
| 19:00 | AFC Knowsley | 0-5 | Litherland REMYCA | Lord Derby Memorial Playing Field | |
| 19:30 | Ashton Athletic | 2-2 | Golborne Sports | Brocstedes Park | |
| Atherton Charity Cup | |||||
| 18:45 | Ashton Town | 1-4 | Euxton Villa | The Bartons Group Stadium | |
| 19:00 | Astley & Buckshawe United | P-P | Thornton Cleveleys | Lostock Skip Hire Community Ground | |
| 19:30 | Burnley Belvedere | P-P | Padiham | Holden Road Burnley | |
| 19:00 | Holker Old Boys | 3-1 | Ulverston Rangers | The Handmark Engineering Stadium | |
| 19:30 | Irlam | 2-2 | Wythenshawe Town | The Silver St Stadium | |
| Friday 18th July 2025 | |||||
| 19:45 | Droylsden | 2-1 | West Didsbury & Chorlton | The Butchers Arms | |
| 19:00 | FC Isle of Man | 2-3 | Fleetwood Town | The Bowl | |
| Isle of Man Festival of Football | |||||
| 19:30 | Nelson | 0-3 | Liversedge | The Daisy Arena Little Wembley | |
| Saturday 19th July 2025 | |||||
| 15:00 | Abbey Hey | 3-4 | Flixton | The Abbey Stadium | |
| 15:00 | AFC Blackpool | 3-2 | Sandbach United | Mechanics Ground | |
| 15:00 | AFC Liverpool | 1-2 | Bootle | Berry Street Garage Stadium | |
| 15:00 | Ashville | 1-1 | South Liverpool | Ray Parker Stadium | |
| 15:00 | Astley and Buckshaw | 2-3 | Fulwood Amateurs | ||
| 12:00 | Barnoldswick Town | 4-0 | Fleetwood Town | Silentnight Stadium | |
| 14:00 | Barnton | 0-2 | 1874 Northwich | The Creative Hut Stadium | |
| 15:00 | Biggleswade Town | 1-1 | Abbey Hulton | ||
| 15:00 | Brocton | 0-2 | Wolverhampton Casuals | Silkmore Lane Sports Ground | |
| 15:00 | Bromyard Town | 3-1 | Allscott Heath | Delahay Meadow | |
| 13:30 | Burscough | 2-1 | Warrington Rylands | The Community Ground | |
| 13:00 | Chadderton | 1-5 | Ashton United | Emplas Commercial North Stadium | |
| 15:00 | Cheadle Heath Nomads | 1-2 | City of Liverpool | Ideal Building Systems Stadium | |
| 13:30 | Cheadle Town | 2-1 | Trafford | The Ground Up Solutions Stadium | |
| 14:00 | Colne | 2-1 | New Mills | Haffners Eats Stadium | |
| 15:00 | Darwen | A-A | Atherton L R | The Anchor Ground | |
| 15:00 | FC St Helens | 3-0 | Runcorn Linnets | SMS PRO SOCCER PARK | |
| 15:00 | Garstang | 0-4 | Ramsbottom United | The Riverside | |
| 00:00 | Haughmond | 4-1 | Church Streton Town | Sundorne Sports Village | |
| 14:00 | Helsby | 2-3 | Stockport Georgians | Helsby Community Sports Centre | |
| 13:00 | Hyde United | 2-1 | Stockport Town | Ewen Fields | |
| 14:00 | Leek Town XI | P-P | Eccleshall | TBC | |
| 15:00 | Longridge Town | 0-6 | Lancaster City | Inglewhite Road | |
| 15:00 | Maghull | 3-2 | Pilkington | DT Hughes Community Stadium | |
| 15:00 | Middlewich Town | 4-1 | Alsager Town | Seddon Street | |
| 15:00 | Millom AFC | 0-1 | Holker Old Boys | ||
| 15:00 | Newcastle Blue Star | 4-0 | Glossop North End | Scotswood Stadium | |
| 15:00 | Newtown AFC | 6-0 | Shawbury United | Latham Park | |
| 15:00 | Old Altrinchamians | 2-2 | Irlam | Crossford Bridge Sports Ground | |
| 00:00 | Padiham | 6-2 | Kendal Town | Ruby Civil Arena | |
| 15:00 | Pause United | 1-5 | Daisy Hill | Trimpell Sports Club | |
| 15:00 | Runcorn Town | 9-0 | Skelmersdale United | Viridor Community Stadium | |
| 13:30 | Seaton Carew | 0-5 | Prestwich Heys | ||
| 15:00 | Squires Gate | 1-3 | Bamber Bridge | The Skiddle Community Stadium | |
| 00:00 | Stafford Town | 1-5 | Chasetown | Evans Park | |
| 15:00 | Steeton | 1-0 | Ilkley Town | Marley Stadium | |
| The Archie Airdrie Trophy | |||||
| 13:30 | Stone Old Aleynians | 3-0 | Foley Meir | Red industries Stadium | |
| 15:00 | Stone Old Alleynians | P-P | Prestwich Heys | Lyme Valley Stadium | |
| 15:00 | Thornton Cleveleys | 3-1 | Charnock Richard | Gamble Road | |
| 00:00 | Uttoxeter Town | 0-1 | Market Drayton Town | Oldfield Sports Ground | |
| 14:00 | Vulcan | 1-3 | MSB Woolton | Volcan Sports Club | |
| 00:00 | Winsford United | 1-0 | Litherland Remyca | Barton Stadium | |
| 14:00 | Wolverhampton Sporting Community | 1-3 | Oldbury United | Pride Park | |
| 15:00 | Wrens Nest | 1-4 | Telford Town | Dudley College 3G | |
| 12:00 | Wythenshawe | 4-1 | Wythenshawe Town | Avensure Community Stadium | |
| Sunday 20th July 2025 | |||||
| 15:00 | FC Isle of Man | 1-3 | Altrincham | The Bowl | |
| Isle of Man Festival of Football | |||||
| Monday 21st July 2025 | |||||
| 19:45 | Ashton Athletic | 2-2 | Ashton Town | Brocstedes Park | |
| Billy Pomfrett & Taffy Roberts Memorial Trophy (3-4 pens) | |||||
| 19:45 | Daisy Hill | 0-3 | Charnock Richard | The Ginge Power Stadium | |
| 00:00 | Stockport Georgians | P-P | Abbey Hey | Cromley Road | |
| 19:30 | Stockport Town | 0-3 | Stalybridge Celtic | Stockport Sports Village | |
| Tuesday 22nd July 2025 | |||||
| 19:45 | 1874 Northwich | 3-0 | Abbey Hey | Townfield | |
| 19:30 | AFC Knowsley | 1-7 | Maghull | ||
| 19:45 | Ashton Athletic | 5-0 | FC United of Manchester | Brocstedes Park | |
| Sam Harding Memorial Trophy | |||||
| 00:00 | Ashton Town | P-P | Widnes | The Bartons Group Stadium | |
| 19:30 | Atherton LR | 3-0 | Cheadle Heath Nomads | Crilly Park | |
| 19:45 | Barnoldswick Town | 2-3 | Lower Breck | Silentnight Stadium | |
| 19:45 | Birstall United | 4-5 | Stafford Town | Meadow Lane | |
| 19:45 | Bury | 9-3 | Cheadle Town | Gigg Lane | |
| 19:30 | Cammell Laird 1907 | 0-6 | Warrington Rylands | The OWS Engineering Ltd Stadium | |
| 19:15 | Denton Town | 2-1 | Droylsden | Whittles Park, Denton, M34 6EJ | |
| Geoff Gable Memorial Trophy | |||||
| 19:30 | Eccleshall | 2-2 | Madeley White Star | Stoke Signage Stadium | |
| 20:00 | Garstang | 0-0 | Lancaster City | The Riverside | |
| 19:45 | Irlam | 2-0 | Congleton Town | The Silver St Stadium | |
| 19:00 | Longridge Town | 2-4 | Bolton Wanderers XI | Inglewhite Road | |
| 19:45 | Mossley | 2-3 | West Didsbury & Chorlton | Seel Park | |
| 19:30 | Padiham | 2-2 | Colne | Ruby Civil Arena | |
| 19:30 | Parklands | 0-0 | Ashville | Parklands Sports Club | |
| 19:30 | Prescot Cables | 4-2 | AFC Liverpool | URETEK Stadium | |
| 19:45 | Ramsbottom United | 2-1 | Fleetwood Town U21 | Harry Williams Riverside Stadium | |
| 19:00 | Redgate Clayton | 2-1 | Foley Meir | Northwood Lane | |
| 18:30 | St Michaels DH | P-P | Litherland Remyca | Ormaston Chadwick Academy | |
| 19:45 | Thornton Cleveleys | 3-2 | Poulton FC | Gamble Road | |
| 19:45 | Wolverhampton Casuals | 0-2 | Stone Old Alleynians | Brinsford Stadium | |
| 00:00 | Wolverhampton Sporting Community | P-P | Sporting Khalsa | Pride Park | |
| Wednesday 23rd July 2025 | |||||
| 19:45 | Cheadle Town | 0-4 | Radcliffe | The Ground Up Solutions Stadium | |
| 19:45 | MSB Woolton | 4-1 | AFC Crewe | Simpsons Hub | |
| 19:45 | Warrington Town | 4-0 | City of Liverpool | Cantilever Park | |
| 20:00 | Wrockwardine Wood | P-P | Telford Town | Telford College 3G | |
| Thursday 24th July 2025 | |||||
| 19:30 | Barnton | P-P | Middlewich Town | The Creative Hut Stadium | |
| 19:30 | Cheadle Heath Nomads | v | Broadheath Central | Ideal Building Systems Stadium | |
| 19:45 | Longridge Town | P-P | Clitheroe | Inglewhite Road | |
| Saturday 26th July 2025 | |||||
| 15:00 | Lower Breck | v | Bacup Borough | Anfield Sports Community Centre | |
| Tuesday 29th July 2025 | |||||
| 19:45 | Darlaston | v | Wolverhampton Casuals | The Paycare Stadium WALSALL | |
| Saturday 2nd August 2025 | |||||
| 15:00 | Ashton Athletic | v | Skelmersdale United | Brocstedes Park | |
| Tuesday 24th June 2025 | |
| Longridge Town 1-1 Chorley Inglewhite Road | |
| Thursday 26th June 2025 | |
| Feniscowles and Pleasington FC 1-5 Longridge Town Feniscowles and Pleasington War Memorial Recreation Ground | |
| Friday 27th June 2025 | |
| Fulwood Amateurs 3-0 Kendal Town Lightfoot Green Lane | |
| Saturday 28th June 2025 | |
| CPD Y Rhyl 1-0 Barnoldswick Town Belle Vue | |
| FC Kirkby 1-3 Ashton Town | |
| Squires Gate 0-1 Chorley The Skiddle Community Stadium | |
| Tuesday 1st July 2025 | |
| Allscott Heath 10-2 Prees United The Giant Stadium | |
| Burscough 3-3 Maghull The Community Ground | |
| Chadderton 1-1 Avro Emplas Commercial North Stadium | |
| Colne 1-2 Wythenshawe Haffners Eats Stadium | |
| Egerton 2-3 Alsager Town Mereheath Lane | |
| Euxton Villa 1-0 Chorley Jim Fowler Memorial Ground | |
| Freckleton 0-0 AFC Blackpool Hodgson Memorial Ground | |
| Glossop North End 2-0 Stockport Georgians The Asgard Engineering Stadium | |
| Gobowen Celtic 3-2 Shawbury United Rhewl Playing Field | |
| Nelson 1-0 Longridge Town The Daisy Arena Little Wembley | |
| Prestwich Heys 1-2 Daisy Hill Adie Moran Park | |
| Sandbach United 5-0 Ball Haye Green Sandbach Community Football Centre | |
| South Liverpool 2-1 Cammell Laird 1907 North Field | |
| Telford Town 3-1 Llansantffraid Shrewsbury College 3G | |
| Wednesday 2nd July 2025 | |
| Altrincham Youth 0-4 Barnton Partington Sports Village | |
| Darwen 1-1 Cheadle Town The Anchor Ground | |
| Garstang 1-2 Atherton LR The Riverside | |
| Maine Road 2-3 Denton Town Wright Robinson College | |
| Marshalls 0-3 Runcorn Town Heron Eccles Playing Fields | |
| Squires Gate 1-4 Pilkington The Skiddle Community Stadium | |
| Thursday 3rd July 2025 | |
| Bilston Town 0-1 Haughmond Queen Street Ground | |
| Burscough 4-0 Burscough Richmond The Community Ground | |
| Chadderton 0-1 Stockport Georgians Emplas Commercial North Stadium | |
| Friday 4th July 2025 | |
| FC Isle of Man 2-3 Isle of Man FA The Bowl | |
| Saturday 5th July 2025 | |
| Abbey Hey 5-0 Maine Road Wright Robinson College | |
| Alsager Town 2-2 Congleton Town Wood Park | |
| Astley & Buckshawe United 1-1 Runcorn Town Lostock Skip Hire Community Ground | |
| Atherton LR 1-1 Bury Crilly Park | |
| Avro 4-0 Droylsden Vestacare Stadium | |
| Barnoldswick Town 9-3 Stockport Georgians Silentnight Stadium | |
| Broadheath Central 0-2 MSB Woolton Balfour Road | |
| Brocton 1-2 Eccleshall St Peters Academy Fenton ST4 2RR | |
| Burscough Richmond 2-3 AFC Blackpool Richmond Park | |
| Chadderton 3-1 Trafford Emplas Commercial North Stadium | |
| Chew Moor Brook 2-1 Charnock Richard | |
| Colwyn Bay 0-1 Stockport Town Llanelian Road | |
| CPD Y Rhyl 0-0 Ashton Town Belle Vue | |
| Dalton United 0-2 Garstang Railway Meadow | |
| Darwen 4-3 Irlam The Anchor Ground | |
| Euxton Villa 2-4 Warrington Rylands Jim Fowler Memorial Ground | |
| Fulwood Amateurs 7-0 Chipping Longridge Town FC | |
| Glossop North End 1-1 New Mills The Asgard Engineering Stadium | |
| Guilsfield P-P Haughmond Community Sports Centre | |
| Holker Old Boys 0-3 Barrow The Handmark Engineering Stadium | |
| Hyde United 1-3 Wythenshawe Ewen Fields | |
| Knutsford 1-2 Barnton Manchester Road | |
| Litherland Remyca P-P Widnes TBC | |
| Longridge Town 3-1 Hurst Green Longridge Town FC | |
| Maghull 2-1 Bootle DT Hughes Community Stadium | |
| Market Drayton Town 2-2 AFC Bridgnorth Greenfields Sports Ground | |
| Nelson 1-2 Ramsbottom United The Daisy Arena Little Wembley | |
| Newtown 1-2 AFC Liverpool Latham Park | |
| Pilkington 1-1 Ashville PSD Stadium | |
| Prestwich Heys 1-2 Atherton Collieries Adie Moran Park | |
| Rainhill Town 2-5 FC St Helens | |
| Rossendale 0-4 Padiham Marl Pits Sports Complex | |
| Route One Rovers 0-0 Daisy Hill Myra Shay | |
| Sandbach United 0-2 Caernarfon Town Sandbach Community Football Centre | |
| Shawbury United 1-0 AFC Wolverhampton City Shrewsbury Sports Village 3G | |
| Squires Gate 1-0 Blackpool XI The Skiddle Community Stadium | |
| Stafford Town 2-3 Lye Town Evans Park | |
| Stockport Town P-P Colwyn Bay (to be played at Colwyn Bay) | |
| Stretford Paddock 0-2 Ashton Athletic | |
| Telford Town 1-3 Gornal Athletic Scat Grass | |
| Thackley 1-3 South Liverpool The Dennyfield | |
| Thornton Cleveleys 4-1 Whitley Bay Gamble Road | |
| Tintwistle Athletic 1-6 Cheadle Town West Drive Football Centre | |
| Vauxhall Motors Reserves P-P Cammell Laird 1907 Vauxhall Motors Sports & Social Club | |
| West Didsbury & Chorlton 8-1 Flixton Hardy Farm Training Pitch | |
| Sunday 6th July 2025 | |
| Hurst Green 2-3 Chipping Longridge Town FC | |
| Longridge Town 3-0 Fullwood Amateurs Longridge Town FC | |
| Monday 7th July 2025 | |
| Market Drayton Town 0-1 Nantwich Town Greenfields Sports Ground | |
| Tuesday 8th July 2025 | |
| Abbey Hey 3-5 Hyde United The Abbey Stadium | |
| AFC Blackpool 1-2 Padiham Mechanics Ground | |
| Aintree Villa 1-1 AFC Liverpool Aintree Racecourse | |
| Allscott Heath 2-2 Church Stretton Town The Giant Stadium | |
| Alsager Town 1-0 Bollington Town Wood Park | |
| Barnoldswick Town 3-0 Silsden Silentnight Stadium | |
| Burscough 2-1 Lancaster City The Community Ground | |
| Chadderton 2-1 Atherton Collieries Emplas Commercial North Stadium | |
| Cheadle Heath Nomads 4-2 Cheadle Town Ideal Building Systems Stadium | |
| Droylsden 1-4 Glossop North End The Butchers Arms | |
| Eccleshall 3-3 Congleton Town Stoke Signage Stadium | |
| Elton Vale 1-5 Ramsbottom United | |
| Euxton Villa 1-2 Runcorn Linnets Jim Fowler Memorial Ground | |
| Foley Meir 1-1 Kidsgrove Athletic Trentham Foods Stadium | |
| Hurst Green 1-1 Nelson San Smithy Ground | |
| Irlam 2-3 Mossley The Silver St Stadium | |
| Llansantffraid 2-3 Shawbury United Recreation Ground | |
| Longridge Town 1-2 Morecambe Inglewhite Road | |
| Maghull 1-1 FC St Helens DT Hughes Community Stadium | |
| New Mills 0-2 Bacup Borough Church Lane | |
| Prestwich Heys 6-3 Thornton Cleveleys Adie Moran Park | |
| Sandbach United 3-0 Sandbach United Reserves Sandbach Community Football Centre | |
| Shifnal Town 3-0 Telford Town Wrekin College | |
| Squires Gate 1-0 Fleetwood Town XI The Skiddle Community Stadium | |
| Stafford Town 2-3 Coleshill Town Evans Park | |
| Steeton 1-3 Campion Marley Stadium | |
| Stockport Georgians 0-3 1874 Northwich Cromley Road | |
| Vauxhall Motors 2-0 South Liverpool The vanEupen Arena | |
| Whalley Range 0-2 West Didsbury & Chorlton Kings Road | |
| Winstanley Warriors 0-3 Ashville Little Lane | |
| Wolstanton United 1-2 Wolverhampton Casuals Keele University | |
| Wednesday 9th July 2025 | |
| AFC Crewe 1-1 Garstang Wood Park Stadium | |
| Daisy Hill 2-2 Radcliffe The Ginge Power Stadium | |
| Dalton United 0-4 Holker Old Boys Railway Meadow | |
| MSB Woolton 2-1 Runcorn Town Simpsons Hub | |
| Penycae 3-1 Haughmond The Riverside Arena | |
| Thursday 10th July 2025 | |
| Brocton 4-0 Market Drayton Town Lilleshall | |
| Daten 1-1 Ashton Athletic WA3 5SH Culcheth, Warrington | |
| Eccleshall P-P Hanley Town Stoke Signage Stadium | |
| Friday 11th July 2025 | |
| FC Isle of Man 2-1 NFA Football The Bowl | |
| Garstang P-P Radcliffe ‘B’ The Riverside | |
| Tempest United 1-1 Daisy Hill | |
| Saturday 12th July 2025 | |
| Abbey Hey 2-3 Tintwistle Athletic The Abbey Stadium | |
| AFC Blackpool 0-2 Ramsbottom United Mechanics Ground | |
| AFC Liverpool P-P Skelmersdale United LCFA Sefton | |
| Airbus UK Broughton 4-3 Burscough Hollingsworth Group Stadium | |
| Alsager Town 0-3 Winsford United Wood Park | |
| Atherstone Town 2-3 Stafford Town Sheepy Road | |
| Barnoldswick Town 1-1 Bootle Silentnight Stadium | |
| Barnton 3-2 Atherton LR The Creative Hut Stadium | |
| Cammell Laird 1907 2-5 1874 Northwich The OWS Engineering Ltd Stadium | |
| Chadderton 1-2 Gresford Athletic Emplas Commercial North Stadium | |
| Cheadle Heath Nomads 0-0 Wythenshawe Town Ideal Building Systems Stadium | |
| Cheadle Town 1-1 Stalybridge Celtic The Ground Up Solutions Stadium | |
| Colne 1-0 Langho Haffners Eats Stadium | |
| Dawley Town P-P Shawbury United Doseley Road Playing Fields | |
| FC Isle of Man 0-3 Brackley Town Ballacloan Stadium, Ramsey | |
| Foley Meir 0-3 Newcastle Town Trentham Foods Stadium | |
| Fulwood Amateurs 1-4 Warrington Rylands Lightfoot Green Lane | |
| Garstang 7-0 Bury Grammer School Old Boys The Riverside | |
| Knutsford 2-1 Sandbach United Manchester Rd Knutsford | |
| Longridge Town 0-4 Bamber Bridge Inglewhite Road | |
| Ludlow Town 2-2 Wolverhampton Casuals Flowfit Stadium | |
| Maghull 1-1 South Liverpool Reserves DT Hughes Community Stadium | |
| Marshalls 1-7 Ashville Heron Eccles | |
| Mossley 0-0 Droylsden Seel Park | |
| MSB Woolton 5-1 Ruthin Town Simpsons Hub | |
| New Mills 1-2 Nelson Church Lane | |
| Newcastle Blue Star P-P Irlam Scotswood Stadium | |
| Old Altrinchamians 5-6 Wythenshawe Crossford Bridge Sports Ground | |
| Padiham P-P Atherton Collieries Ruby Civil Arena | |
| Penrith 2-2 Charnock Richard Frenchfield Park | |
| Pilkington 2-3 Lower Breck PSD Stadium | |
| Redgate Clayton 1-2 Eccleshall Northwood Lane | |
| Rossendale 4-1 Ashton Athletic | |
| Route One Rovers 1-3 Bacup Borough Myra Shay | |
| Runcorn Town 2-2 FC St Helens Viridor Community Stadium | |
| Squires Gate 0-6 Radcliffe The Skiddle Community Stadium | |
| Steeton 3-1 Nostell Miners Welfare Marley Stadium | |
| Stockport Georgians 1-3 Prestwich Heys Cromley Road | |
| Stockport Town 4-0 Chadertonians Stockport Sports Village | |
| Stockport Town P-P Darwen Stockport Sports Village | |
| Telford Town 0-3 Stafford Rangers DRM Aggregate Arena | |
| Thornton Cleveleys 1-0 Upper Mill Gamble Road | |
| Vauxhall Motors Res 0-1 AFC Liverpool | |
| West Didsbury & Chorlton 1-1 Maine Road Brookburn Road (3-5 on )Pens | |
| Witton Albion 2-1 Litherland REMYCA Wincham Park | |
| Monday 14th July 2025 | |
| Stockport Town 7-0 Denton Town Stockport Sports Village | |
| Stockport Town P-P Accrington Stanley U21 Stockport Sports Village | |
| Tuesday 15th July 2025 | |
| Abbey Hey 3-2 Glossop North End The Abbey Stadium | |
| AFC Knowsley 0-4 Burscough Lord Derby Memorial Playing Field | |
| Allscott Heath 2-2 FC Nations The Giant Stadium | |
| Alsager Town 1-9 Hanley Town Wood Park | |
| Ashton Town 10-4 Hindsford The Bartons Group Stadium | |
| Atherton Collieries 1-1 West Didsbury & Chorlton The Kensite Stadium | |
| Atherton LR 2-2 Maine Road Crilly Park | |
| Barnton P-P St Helens Town The Creative Hut Stadium | |
| Blackpool Wren Rovers 1-2 FC St Helens Brews Park | |
| Bury 2-1 Ashton Athletic Gigg Lane | |
| Cammell Laird 1907 2-2 Litherland Remyca The OWS Engineering Ltd Stadium | |
| Chadderton 2-2 Bacup Borough Emplas Commercial North Stadium | |
| Cheadle Heath Nomads 1-4 Wythenshawe Ideal Building Systems Stadium | |
| Cheadle Town 3-0 Mossley The Ground Up Solutions Stadium | |
| Colne 0-0 Hurst Green Haffners Eats Stadium | |
| Droylsden P-P CPD Rhyl The Butchers Arms | |
| Droylsden 2-4 1874 Northwich The Butchers Arms | |
| Ercall Colts P-P Wolverhampton Casuals Hadley Learning Centre | |
| Flixton 1-5 New Mills | |
| Foley Meir 0-3 Crewe Alexandra Trentham Foods Stadium | |
| Fulwood Amateurs 3-0 Pause United UCLAN Sports Arena | |
| Irlam 2-2 Trafford The Silver St Stadium | |
| Kidsgrove Athletic 1-1 Abbey Hulton Autonet Insurance Stadium | |
| Liversedge 3-1 Steeton The Leading Edge Clayborn Ground | |
| Maghull 0-5 Warrington Town DT Hughes Community Stadium | |
| Market Drayton Town 1-0 Port Vale Academy Greenfields Sports Ground | |
| Nelson 3-3 Barnoldswick Town The Daisy Arena Little Wembley | |
| OJM Birmingham 2-4 Telford Town | |
| Padiham 4-1 Daisy Hill Ruby Civil Arena | |
| Prees United P-P Barnton Prees Recreation Club | |
| Prestwich Heys 1-0 FC United of Manchester Adie Moran Park | |
| Rossendale 0-3 Charnock Richard Marl Pits Sports Centre, BB4 7SN | |
| Runcorn Town 4-1 Witton Albion Viridor Community Stadium | |
| Sandbach United 1-0 Pilkington Sandbach Community Football Centre | |
| Shawbury United 3-2 Wrockardine Wood London Road SCAT 3G | |
| Squires Gate 3-2 Galgate FC The Skiddle Community Stadium | |
| Stalybridge Celtic P-P Darwen Bower Fold | |
| Stockport Georgians 2-1 FC Halifax Town U19 Cromley Road | |
| Stone Old Alleynians 1-0 Stafford Town Roe Lane ST5 3PH | |
| Telford Town 4-2 Birmingham OJM DRM Aggregate Arena | |
| Wednesday 16th July 2025 | |
| Darwen 2-1 Stalybridge Celtic The Anchor Ground | |
| Eccleshall 4-1 Silverdale Athletic Stoke Signage Stadium | |
| Helsby 0-4 Ashville Helsby Community Sports Centre | |
| Little Lever SC 3-0 Atherton LR Lytham Road | |
| MSB Woolton 2-0 AFC Liverpool Simpsons Hub | |
| Shifnal Town Development 1-4 Haughmond Acoustafoam Stadium, TF11 8PD | |
| South Liverpool 0-4 Lower Breck Jericho Lane | |
| Thursday 17th July 2025 | |
| AFC Knowsley 0-5 Litherland REMYCA Lord Derby Memorial Playing Field | |
| Ashton Athletic 2-2 Golborne Sports Brocstedes Park | |
| Ashton Town 1-4 Euxton Villa The Bartons Group Stadium | |
| Astley & Buckshawe United P-P Thornton Cleveleys Lostock Skip Hire Community Ground | |
| Burnley Belvedere P-P Padiham Holden Road Burnley | |
| Holker Old Boys 3-1 Ulverston Rangers The Handmark Engineering Stadium | |
| Irlam 2-2 Wythenshawe Town The Silver St Stadium | |
| Friday 18th July 2025 | |
| Droylsden 2-1 West Didsbury & Chorlton The Butchers Arms | |
| FC Isle of Man 2-3 Fleetwood Town The Bowl | |
| Nelson 0-3 Liversedge The Daisy Arena Little Wembley | |
| Saturday 19th July 2025 | |
| Abbey Hey 3-4 Flixton The Abbey Stadium | |
| AFC Blackpool 3-2 Sandbach United Mechanics Ground | |
| AFC Liverpool 1-2 Bootle Berry Street Garage Stadium | |
| Ashville 1-1 South Liverpool Ray Parker Stadium | |
| Astley and Buckshaw 2-3 Fulwood Amateurs | |
| Barnoldswick Town 4-0 Fleetwood Town Silentnight Stadium | |
| Barnton 0-2 1874 Northwich The Creative Hut Stadium | |
| Biggleswade Town 1-1 Abbey Hulton | |
| Brocton 0-2 Wolverhampton Casuals Silkmore Lane Sports Ground | |
| Bromyard Town 3-1 Allscott Heath Delahay Meadow | |
| Burscough 2-1 Warrington Rylands The Community Ground | |
| Chadderton 1-5 Ashton United Emplas Commercial North Stadium | |
| Cheadle Heath Nomads 1-2 City of Liverpool Ideal Building Systems Stadium | |
| Cheadle Town 2-1 Trafford The Ground Up Solutions Stadium | |
| Colne 2-1 New Mills Haffners Eats Stadium | |
| Darwen A-A Atherton L R The Anchor Ground | |
| FC St Helens 3-0 Runcorn Linnets SMS PRO SOCCER PARK | |
| Garstang 0-4 Ramsbottom United The Riverside | |
| Haughmond 4-1 Church Streton Town Sundorne Sports Village | |
| Helsby 2-3 Stockport Georgians Helsby Community Sports Centre | |
| Hyde United 2-1 Stockport Town Ewen Fields | |
| Leek Town XI P-P Eccleshall TBC | |
| Longridge Town 0-6 Lancaster City Inglewhite Road | |
| Maghull 3-2 Pilkington DT Hughes Community Stadium | |
| Middlewich Town 4-1 Alsager Town Seddon Street | |
| Millom AFC 0-1 Holker Old Boys | |
| Newcastle Blue Star 4-0 Glossop North End Scotswood Stadium | |
| Newtown AFC 6-0 Shawbury United Latham Park | |
| Old Altrinchamians 2-2 Irlam Crossford Bridge Sports Ground | |
| Padiham 6-2 Kendal Town Ruby Civil Arena | |
| Pause United 1-5 Daisy Hill Trimpell Sports Club | |
| Runcorn Town 9-0 Skelmersdale United Viridor Community Stadium | |
| Seaton Carew 0-5 Prestwich Heys | |
| Squires Gate 1-3 Bamber Bridge The Skiddle Community Stadium | |
| Stafford Town 1-5 Chasetown Evans Park | |
| Steeton 1-0 Ilkley Town Marley Stadium | |
| Stone Old Aleynians 3-0 Foley Meir Red industries Stadium | |
| Stone Old Alleynians P-P Prestwich Heys Lyme Valley Stadium | |
| Thornton Cleveleys 3-1 Charnock Richard Gamble Road | |
| Uttoxeter Town 0-1 Market Drayton Town Oldfield Sports Ground | |
| Vulcan 1-3 MSB Woolton Volcan Sports Club | |
| Winsford United 1-0 Litherland Remyca Barton Stadium | |
| Wolverhampton Sporting Community 1-3 Oldbury United Pride Park | |
| Wrens Nest 1-4 Telford Town Dudley College 3G | |
| Wythenshawe 4-1 Wythenshawe Town Avensure Community Stadium | |
| Sunday 20th July 2025 | |
| FC Isle of Man 1-3 Altrincham The Bowl | |
| Monday 21st July 2025 | |
| Ashton Athletic 2-2 Ashton Town Brocstedes Park | |
| Daisy Hill 0-3 Charnock Richard The Ginge Power Stadium | |
| Stockport Georgians P-P Abbey Hey Cromley Road | |
| Stockport Town 0-3 Stalybridge Celtic Stockport Sports Village | |
| Tuesday 22nd July 2025 | |
| 1874 Northwich 3-0 Abbey Hey Townfield | |
| AFC Knowsley 1-7 Maghull | |
| Ashton Athletic 5-0 FC United of Manchester Brocstedes Park | |
| Ashton Town P-P Widnes The Bartons Group Stadium | |
| Atherton LR 3-0 Cheadle Heath Nomads Crilly Park | |
| Barnoldswick Town 2-3 Lower Breck Silentnight Stadium | |
| Birstall United 4-5 Stafford Town Meadow Lane | |
| Bury 9-3 Cheadle Town Gigg Lane | |
| Cammell Laird 1907 0-6 Warrington Rylands The OWS Engineering Ltd Stadium | |
| Denton Town 2-1 Droylsden Whittles Park, Denton, M34 6EJ | |
| Eccleshall 2-2 Madeley White Star Stoke Signage Stadium | |
| Garstang 0-0 Lancaster City The Riverside | |
| Irlam 2-0 Congleton Town The Silver St Stadium | |
| Longridge Town 2-4 Bolton Wanderers XI Inglewhite Road | |
| Mossley 2-3 West Didsbury & Chorlton Seel Park | |
| Padiham 2-2 Colne Ruby Civil Arena | |
| Parklands 0-0 Ashville Parklands Sports Club | |
| Prescot Cables 4-2 AFC Liverpool URETEK Stadium | |
| Ramsbottom United 2-1 Fleetwood Town U21 Harry Williams Riverside Stadium | |
| Redgate Clayton 2-1 Foley Meir Northwood Lane | |
| St Michaels DH P-P Litherland Remyca Ormaston Chadwick Academy | |
| Thornton Cleveleys 3-2 Poulton FC Gamble Road | |
| Wolverhampton Casuals 0-2 Stone Old Alleynians Brinsford Stadium | |
| Wolverhampton Sporting Community P-P Sporting Khalsa Pride Park | |
| Wednesday 23rd July 2025 | |
| Cheadle Town 0-4 Radcliffe The Ground Up Solutions Stadium | |
| MSB Woolton 4-1 AFC Crewe Simpsons Hub | |
| Warrington Town 4-0 City of Liverpool Cantilever Park | |
| Wrockwardine Wood P-P Telford Town Telford College 3G | |
| Thursday 24th July 2025 | |
| Barnton P-P Middlewich Town The Creative Hut Stadium | |
| Cheadle Heath Nomads v Broadheath Central Ideal Building Systems Stadium | |
| Longridge Town P-P Clitheroe Inglewhite Road | |
| Saturday 26th July 2025 | |
| Lower Breck v Bacup Borough Anfield Sports Community Centre | |
| Tuesday 29th July 2025 | |
| Darlaston v Wolverhampton Casuals The Paycare Stadium WALSALL | |
| Saturday 2nd August 2025 | |
| Ashton Athletic v Skelmersdale United Brocstedes Park | |
