| Wednesday 29th October 2025 | The Edward Case Cup 1st Round North | ||
| 19:45 |  Darwen FC v Colne  | Multevo Group Anchor Ground | |
| 19:45 |  Nelson v MSB Woolton  | Inglewhite Road | |
| Played at Longridge Town | |||
| 19:45 |  Thornton Cleveleys v Maine Road  | Gamble Road | |
| 20:00 |  Bacup Borough v Holker Old Boys  | Brian Boys West View Stadium | |
| Wednesday 29th October 2025 | The Edward Case Cup 1st Round South | ||
| 19:45 |  Telford Town v Eccleshall  | DRM Aggregate Arena | |
| Wednesday 29th October 2025 | Premier Division | ||
| 19:45 |  Litherland REMYCA v Padiham  | Litherland Sports Park | |
| 19:45 |  West Didsbury & Chorlton v Irlam  | Step Places Stadium | |
| Saturday 1st November 2025 | The Isuzu FA Vase 1st Rnd | ||
| 15:00 | Holker Old Boys v Wythenshawe  | The Handmark Engineering Stadium | |
| Saturday 1st November 2025 | Premier Division | ||
| 14:00 |  Cheadle Town v FC St Helens  | The Ground Up Solutions Stadium | |
| 15:00 |  Abbey Hey v South Liverpool  | The Abbey Stadium | |
| 15:00 |  Atherton LR v Glossop North End  | Crilly Park | |
| 15:00 |  Barnoldswick Town v Burscough  | Silentnight Stadium | |
| 15:00 |  Charnock Richard v Litherland REMYCA | Mossie Park | |
| 15:00 |  City of Liverpool v Euxton Villa  | The Community Ground | |
| 15:00 | Irlam v Padiham | The Silver St Stadium | |
| 15:00 |  Pilkington v West Didsbury & Chorlton | PSD Stadium | |
| 15:00 |  Prestwich Heys v Ramsbottom United  | Adie Moran Park | |
| 15:00 |  Stockport Town v Chadderton  | Stockport Sports Village | |
| 18:00 |  FC Isle of Man v Longridge Town  | The Bowl | |
| Saturday 1st November 2025 | First Division North | ||
| 15:00 |  AFC Blackpool v Steeton  | Mechanics Ground | |
| 15:00 |  Ashton Town v Thornton Cleveleys | The Bartons Group Stadium | |
| 15:00 |  Daisy Hill v Squires Gate  | The Ginge Power Stadium | |
| 15:00 | Darwen FC v Ashton Athletic  | Multevo Group Anchor Ground | |
| 15:00 |  Fulwood Amateurs v Droylsden  | Lightfoot Green Lane | |
| 15:00 |  Maghull v Maine Road | DT Hughes Community Stadium | |
| 15:00 | MSB Woolton v Colne | Jericho Lane | |
| 15:00 | Nelson v Garstang  | The Daisy Arena Little Wembley | |
| Saturday 1st November 2025 | First Division South | ||
| 15:00 |  Alsager Town v Cammell Laird 1907  | Wood Park | |
| 15:00 |  Ashville v Sandbach United  | Ray Parker Stadium | |
| 15:00 |  Cheadle Heath Nomads v Haughmond  | Ideal Building Systems Stadium | |
| 15:00 |  Foley Meir v Wolverhampton Sporting Community  | Trentham Foods Stadium | |
| 15:00 |  New Mills v Market Drayton Town  | Church Lane | |
| 15:00 |  Shawbury United v Allscott Heath  | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 |  Stockport Georgians v Stafford Town  | Cromley Road | |
| 15:00 | Telford Town v Runcorn Town  | DRM Aggregate Arena | |
| 15:00 |  Wolverhampton Casuals v Eccleshall | Brinsford Stadium | |
| Monday 3rd November 2025 | Premier Division | ||
| 19:45 | Stockport Town v Burscough | Stockport Sports Village | |
| Monday 3rd November 2025 | First Division North | ||
| 19:45 | Daisy Hill v Colne | The Ginge Power Stadium | |
| Tuesday 4th November 2025 | Premier Division | ||
| 19:45 | Atherton LR v Longridge Town | Crilly Park | |
| 19:45 | Cheadle Town v West Didsbury & Chorlton | The Ground Up Solutions Stadium | |
| 19:45 | Irlam v Chadderton | The Silver St Stadium | |
| 19:45 | Padiham v Abbey Hey | Ruby Civil Arena | |
| 19:45 | Ramsbottom United v Barnoldswick Town | Harry Williams Riverside Stadium | |
| 20:00 | Euxton Villa v FC Isle of Man | Jim Fowler Memorial Ground | |
| Tuesday 4th November 2025 | Derbyshire Senior Cup 2nd Rnd | ||
| 19:45 |  Shirebrook Town v Glossop North End | Shirebrook Staff Sports and Social Club | |
| Tuesday 4th November 2025 | Walsall Senior Cup 1st Rnd | ||
| 19:45 | Wolverhampton Casuals v Coleshill Town  | Brinsford Stadium | |
| Wednesday 5th November 2025 | Premier Division | ||
| 19:45 |  AFC Liverpool v Prestwich Heys | Berry Street Garage Stadium | |
| 19:45 | South Liverpool v Charnock Richard | Jericho Lane | |
| Wednesday 5th November 2025 | Staffordshire Senior Cup 2nd Rnd | ||
| 19:45 | Eccleshall v Abbey Hulton United  | Stoke Signage Stadium | |
| Saturday 8th November 2025 | The Isuzu FA Vase 2nd Rnd | ||
| 15:00 | Barnoldswick Town v Winsford United  | Silentnight Stadium | |
| 15:00 |  Brigg Town v West Didsbury & Chorlton | The EC Surfacing Stadium | |
| 15:00 | Burscough v Ashton Town | The Community Ground | |
| 15:00 | Charnock Richard v Nelson | Mossie Park | |
| 15:00 | Cheadle Town v North Shields  | The Ground Up Solutions Stadium | |
| 15:00 |  Crook Town v Ramsbottom United | The Sir Tom Cowie Millfield Ground | |
| 15:00 | Droylsden v Northwich Victoria  | The Butchers Arms | |
| 15:00 |  Liversedge v Atherton LR | Clayborn Ground | |
| 15:00 | Prestwich Heys v Irlam | Adie Moran Park | |
| 15:00 |  Redcar Town v Chadderton | Mo Mowlam Memorial Park | |
| 15:00 | South Liverpool v Barton Town  | Jericho Lane | |
| 15:00 |  Yarm & Eaglescliffe v Fulwood Amateurs | Sovereign Supply Chain Stadium | |
| Saturday 8th November 2025 | Premier Division | ||
| 15:00 | Abbey Hey v Wythenshawe | The Abbey Stadium | |
| 15:00 | City of Liverpool v AFC Liverpool | The Community Ground | |
| 15:00 | FC St Helens v Padiham | SMS PRO SOCCER PARK | |
| 15:00 | Longridge Town v Euxton Villa | Inglewhite Road | |
| 15:00 | Stockport Town v Glossop North End | Stockport Sports Village | |
| 18:00 | FC Isle of Man v Pilkington | The Bowl | |
| Saturday 8th November 2025 | First Division North | ||
| 15:00 | Ashton Athletic v AFC Blackpool | Brocstedes Park | |
| 15:00 | Colne v Darwen FC | Haffners Eats Stadium | |
| 15:00 | Garstang v Maghull | The Riverside | |
| 15:00 | Holker Old Boys v AFC Blackpool | The Handmark Engineering Stadium | |
| 15:00 | Squires Gate v MSB Woolton | The Skiddle Community Stadium | |
| 15:00 | Steeton v Daisy Hill | Marley Stadium | |
| 15:00 | Thornton Cleveleys v Bacup Borough | Gamble Road | |
| Saturday 8th November 2025 | First Division South | ||
| 15:00 |  Barnton v Foley Meir | The Creative Hut Stadium | |
| 15:00 | Cammell Laird 1907 v New Mills | The OWS Engineering Ltd Stadium | |
| 15:00 | Eccleshall v Ashville | Stoke Signage Stadium | |
| 15:00 | Market Drayton Town v Cheadle Heath Nomads | Greenfields Sports Ground | |
| 15:00 | Runcorn Town v Stockport Georgians | Viridor Community Stadium | |
| 15:00 | Sandbach United v Allscott Heath | Sandbach Community Football Centre | |
| 15:00 | Shawbury United v Alsager Town | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Telford Town v Wolverhampton Sporting Community | DRM Aggregate Arena | |
| 15:00 | Wolverhampton Casuals v Haughmond | Brinsford Stadium | |
| Tuesday 11th November 2025 | Premier Division | ||
| 19:45 | Atherton LR v Irlam | Crilly Park | |
| 19:45 | Barnoldswick Town v Longridge Town | Silentnight Stadium | |
| 19:45 | Cheadle Town v Chadderton | The Ground Up Solutions Stadium | |
| 19:45 | Padiham v Charnock Richard | Ruby Civil Arena | |
| 19:45 | Prestwich Heys v Abbey Hey | Adie Moran Park | |
| 19:45 | Wythenshawe v Ramsbottom United | Avensure Community Stadium | |
| 20:00 | Euxton Villa v AFC Liverpool | Jim Fowler Memorial Ground | |
| Tuesday 11th November 2025 | First Division North | ||
| 19:45 | Colne v AFC Blackpool | Haffners Eats Stadium | |
| Tuesday 11th November 2025 | First Division South | ||
| 19:45 | Wolverhampton Casuals v Shawbury United | Brinsford Stadium | |
| Wednesday 12th November 2025 | Premier Division | ||
| 19:45 | West Didsbury & Chorlton v City of Liverpool | Step Places Stadium | |
| Wednesday 12th November 2025 | First Division North | ||
| 19:45 | MSB Woolton v Steeton | Jericho Lane | |
| 19:45 | Nelson v Fulwood Amateurs | The Daisy Arena Little Wembley | |
| Thursday 13th November 2025 | Cheshire Senior Cup 1st Rnd | ||
| 20:00 |  Crewe Alexandra v Barnton | Gresty Road | |
| Friday 14th November 2025 | Premier Division | ||
| 19:45 | Atherton LR v Prestwich Heys | Crilly Park | |
| 19:45 | FC St Helens v South Liverpool | SMS PRO SOCCER PARK | |
| Friday 14th November 2025 | First Division South | ||
| 19:45 | Ashville v New Mills | Ray Parker Stadium | |
| Saturday 15th November 2025 | Premier Division | ||
| 15:00 | AFC Liverpool v Longridge Town | Berry Street Garage Stadium | |
| 15:00 | Burscough v Glossop North End | The Community Ground | |
| 15:00 | Chadderton v City of Liverpool | Emplas Commercial North Stadium | |
| 15:00 | Charnock Richard v Cheadle Town | Mossie Park | |
| 15:00 | Irlam v Abbey Hey | The Silver St Stadium | |
| 15:00 | Ramsbottom United v Pilkington | Harry Williams Riverside Stadium | |
| 15:00 | Stockport Town v Barnoldswick Town | Stockport Sports Village | |
| 15:00 | Wythenshawe v Euxton Villa | Avensure Community Stadium | |
| 18:00 | FC Isle of Man v West Didsbury & Chorlton | The Bowl | |
| Saturday 15th November 2025 | First Division North | ||
| 15:00 | Ashton Athletic v Garstang | Brocstedes Park | |
| 15:00 | Ashton Town v Droylsden | The Bartons Group Stadium | |
| 15:00 | Colne v Thornton Cleveleys | Haffners Eats Stadium | |
| 15:00 | Daisy Hill v AFC Blackpool | The Ginge Power Stadium | |
| 15:00 | Darwen FC v Bacup Borough | Multevo Group Anchor Ground | |
| 15:00 | Fulwood Amateurs v Maine Road | Lightfoot Green Lane | |
| 15:00 | Holker Old Boys v Maghull | The Handmark Engineering Stadium | |
| 15:00 | MSB Woolton v Nelson | Jericho Lane | |
| 15:00 | Squires Gate v Steeton | The Skiddle Community Stadium | |
| Saturday 15th November 2025 | First Division South | ||
| 15:00 | Allscott Heath v Market Drayton Town | The Giant Stadium | |
| 15:00 | Alsager Town v Barnton | Wood Park | |
| 15:00 | Cheadle Heath Nomads v Stafford Town | Ideal Building Systems Stadium | |
| 15:00 | Foley Meir v Shawbury United | Trentham Foods Stadium | |
| 15:00 | Haughmond v Cammell Laird 1907 | Sundorne Sports Village | |
| 15:00 | Sandbach United v Wolverhampton Casuals | Sandbach Community Football Centre | |
| 15:00 | Stockport Georgians v Telford Town | Cromley Road | |
| 15:00 | Wolverhampton Sporting Community v Runcorn Town | Pride Park | |
| Monday 17th November 2025 | Cheshire Senior Cup 2nd Rnd | ||
| 19:45 | Stockport Town v Warrington Town  | Stockport Sports Village | |
| Tuesday 18th November 2025 | Premier Division | ||
| 19:45 | Barnoldswick Town v Abbey Hey | Silentnight Stadium | |
| 19:45 | Cheadle Town v Litherland REMYCA | The Ground Up Solutions Stadium | |
| 19:45 | City of Liverpool v Ramsbottom United | The Community Ground | |
| 19:45 | Glossop North End v FC St Helens | The Asgard Engineering Stadium | |
| Tuesday 18th November 2025 | Lancashire Challenge Trophy 2nd Rnd | ||
| 19:45 | Ashton Athletic v Lancaster City  | Brocstedes Park | |
| 19:45 | Fulwood Amateurs v AFC Fylde  | Lightfoot Green Lane | |
| 19:45 | Longridge Town v Daisy Hill | Inglewhite Road | |
| 19:45 | Prestwich Heys v Padiham | Adie Moran Park | |
| 19:45 | Squires Gate v Nelson | The Skiddle Community Stadium | |
| Tuesday 18th November 2025 | Liverpool Senior Cup Prelim Rnd | ||
| 19:45 | MSB Woolton v Bootle  | Berry Street Garage Stadium | |
| Played at Bootle | |||
| Tuesday 18th November 2025 | Manchester Premier Cup Prelim Rnd | ||
| 19:45 |  Ashton United v Chadderton | Hurst Cross | |
| 19:45 |  Radcliffe v Irlam | Stainton Park | |
| Wednesday 19th November 2025 | Lancashire Challenge Trophy 2nd Rnd | ||
| 19:45 | West Didsbury & Chorlton v Clitheroe  | Step Places Stadium | |
| 20:00 | Garstang v Wythenshawe | The Riverside | |
| Wednesday 29th October 2025 The Edward Case Cup 1st Round North |
|
| Darwen FC v Colne (19:45) | |
| Nelson v MSB Woolton (19:45) | |
| Played at Longridge Town | |
| Thornton Cleveleys v Maine Road (19:45) | |
| Bacup Borough v Holker Old Boys (20:00) | |
| Wednesday 29th October 2025 The Edward Case Cup 1st Round South |
| Telford Town v Eccleshall (19:45) |
| Wednesday 29th October 2025 Premier Division |
| Litherland REMYCA v Padiham (19:45) |
| West Didsbury & Chorlton v Irlam (19:45) |
| Saturday 1st November 2025 The Isuzu FA Vase 1st Round |
| Holker Old Boys v Wythenshawe (15:00) |
| Saturday 1st November 2025 Premier Division |
| Cheadle Town v FC St Helens (14:00) |
| Abbey Hey v South Liverpool (15:00) |
| Atherton LR v Glossop North End (15:00) |
| Barnoldswick Town v Burscough (15:00) |
| Charnock Richard v Litherland REMYCA (15:00) |
| City of Liverpool v Euxton Villa (15:00) |
| Irlam v Padiham (15:00) |
| Pilkington v West Didsbury & Chorlton (15:00) |
| Prestwich Heys v Ramsbottom United (15:00) |
| Stockport Town v Chadderton (15:00) |
| FC Isle of Man v Longridge Town (18:00) |
| Saturday 1st November 2025 First Division North |
| AFC Blackpool v Steeton (15:00) |
| Ashton Town v Thornton Cleveleys (15:00) |
| Daisy Hill v Squires Gate (15:00) |
| Darwen FC v Ashton Athletic (15:00) |
| Fulwood Amateurs v Droylsden (15:00) |
| Maghull v Maine Road (15:00) |
| MSB Woolton v Colne (15:00) |
| Nelson v Garstang (15:00) |
| Saturday 1st November 2025 First Division South |
| Alsager Town v Cammell Laird 1907 (15:00) |
| Ashville v Sandbach United (15:00) |
| Cheadle Heath Nomads v Haughmond (15:00) |
| Foley Meir v Wolverhampton Sporting Community (15:00) |
| New Mills v Market Drayton Town (15:00) |
| Shawbury United v Allscott Heath (15:00) |
| Stockport Georgians v Stafford Town (15:00) |
| Telford Town v Runcorn Town (15:00) |
| Wolverhampton Casuals v Eccleshall (15:00) |
| Monday 3rd November 2025 Premier Division |
| Stockport Town v Burscough (19:45) |
| Monday 3rd November 2025 First Division North |
| Daisy Hill v Colne (19:45) |
| Tuesday 4th November 2025 Premier Division |
| Atherton LR v Longridge Town (19:45) |
| Cheadle Town v West Didsbury & Chorlton (19:45) |
| Irlam v Chadderton (19:45) |
| Padiham v Abbey Hey (19:45) |
| Ramsbottom United v Barnoldswick Town (19:45) |
| Euxton Villa v FC Isle of Man (20:00) |
| Tuesday 4th November 2025 Derbyshire Senior Cup 2nd Round |
| Shirebrook Town v Glossop North End (19:45) |
| Tuesday 4th November 2025 Walsall Senior Cup 1st Round |
| Wolverhampton Casuals v Coleshill Town (19:45) |
| Wednesday 5th November 2025 Premier Division |
| AFC Liverpool v Prestwich Heys (19:45) |
| South Liverpool v Charnock Richard (19:45) |
| Wednesday 5th November 2025 Staffordshire Senior Cup 2nd Round |
| Eccleshall v Abbey Hulton United (19:45) |
| Saturday 8th November 2025 The Isuzu FA Vase 2nd Round |
| Barnoldswick Town v Winsford United (15:00) |
| Brigg Town v West Didsbury & Chorlton (15:00) |
| Burscough v Ashton Town (15:00) |
| Charnock Richard v Nelson (15:00) |
| Cheadle Town v North Shields (15:00) |
| Crook Town v Ramsbottom United (15:00) |
| Droylsden v Northwich Victoria (15:00) |
| Liversedge v Atherton LR (15:00) |
| Prestwich Heys v Irlam (15:00) |
| Redcar Town v Chadderton (15:00) |
| South Liverpool v Barton Town (15:00) |
| Yarm & Eaglescliffe v Fulwood Amateurs (15:00) |
| Saturday 8th November 2025 Premier Division |
| Abbey Hey v Wythenshawe (15:00) |
| City of Liverpool v AFC Liverpool (15:00) |
| FC St Helens v Padiham (15:00) |
| Longridge Town v Euxton Villa (15:00) |
| Stockport Town v Glossop North End (15:00) |
| FC Isle of Man v Pilkington (18:00) |
| Saturday 8th November 2025 First Division North |
| Ashton Athletic v AFC Blackpool (15:00) |
| Colne v Darwen FC (15:00) |
| Garstang v Maghull (15:00) |
| Holker Old Boys v AFC Blackpool (15:00) |
| Squires Gate v MSB Woolton (15:00) |
| Steeton v Daisy Hill (15:00) |
| Thornton Cleveleys v Bacup Borough (15:00) |
| Saturday 8th November 2025 First Division South |
| Barnton v Foley Meir (15:00) |
| Cammell Laird 1907 v New Mills (15:00) |
| Eccleshall v Ashville (15:00) |
| Market Drayton Town v Cheadle Heath Nomads (15:00) |
| Runcorn Town v Stockport Georgians (15:00) |
| Sandbach United v Allscott Heath (15:00) |
| Shawbury United v Alsager Town (15:00) |
| Telford Town v Wolverhampton Sporting Community (15:00) |
| Wolverhampton Casuals v Haughmond (15:00) |
| Tuesday 11th November 2025 Premier Division |
| Atherton LR v Irlam (19:45) |
| Barnoldswick Town v Longridge Town (19:45) |
| Cheadle Town v Chadderton (19:45) |
| Padiham v Charnock Richard (19:45) |
| Prestwich Heys v Abbey Hey (19:45) |
| Wythenshawe v Ramsbottom United (19:45) |
| Euxton Villa v AFC Liverpool (20:00) |
| Tuesday 11th November 2025 First Division North |
| Colne v AFC Blackpool (19:45) |
| Tuesday 11th November 2025 First Division South |
| Wolverhampton Casuals v Shawbury United (19:45) |
| Wednesday 12th November 2025 Premier Division |
| West Didsbury & Chorlton v City of Liverpool (19:45) |
| Wednesday 12th November 2025 First Division North |
| MSB Woolton v Steeton (19:45) |
| Nelson v Fulwood Amateurs (19:45) |
| Thursday 13th November 2025 Cheshire Senior Cup 1st Round |
| Crewe Alexandra v Barnton (20:00) |
| Friday 14th November 2025 Premier Division |
| Atherton LR v Prestwich Heys (19:45) |
| FC St Helens v South Liverpool (19:45) |
| Friday 14th November 2025 First Division South |
| Ashville v New Mills (19:45) |
| Saturday 15th November 2025 Premier Division |
| AFC Liverpool v Longridge Town (15:00) |
| Burscough v Glossop North End (15:00) |
| Chadderton v City of Liverpool (15:00) |
| Charnock Richard v Cheadle Town (15:00) |
| Irlam v Abbey Hey (15:00) |
| Ramsbottom United v Pilkington (15:00) |
| Stockport Town v Barnoldswick Town (15:00) |
| Wythenshawe v Euxton Villa (15:00) |
| FC Isle of Man v West Didsbury & Chorlton (18:00) |
| Saturday 15th November 2025 First Division North |
| Ashton Athletic v Garstang (15:00) |
| Ashton Town v Droylsden (15:00) |
| Colne v Thornton Cleveleys (15:00) |
| Daisy Hill v AFC Blackpool (15:00) |
| Darwen FC v Bacup Borough (15:00) |
| Fulwood Amateurs v Maine Road (15:00) |
| Holker Old Boys v Maghull (15:00) |
| MSB Woolton v Nelson (15:00) |
| Squires Gate v Steeton (15:00) |
| Saturday 15th November 2025 First Division South |
| Allscott Heath v Market Drayton Town (15:00) |
| Alsager Town v Barnton (15:00) |
| Cheadle Heath Nomads v Stafford Town (15:00) |
| Foley Meir v Shawbury United (15:00) |
| Haughmond v Cammell Laird 1907 (15:00) |
| Sandbach United v Wolverhampton Casuals (15:00) |
| Stockport Georgians v Telford Town (15:00) |
| Wolverhampton Sporting Community v Runcorn Town (15:00) |
| Monday 17th November 2025 Cheshire Senior Cup 2nd Round |
| Stockport Town v Warrington Town (19:45) |
| Tuesday 18th November 2025 Premier Division |
| Barnoldswick Town v Abbey Hey (19:45) |
| Cheadle Town v Litherland REMYCA (19:45) |
| City of Liverpool v Ramsbottom United (19:45) |
| Glossop North End v FC St Helens (19:45) |
| Tuesday 18th November 2025 Lancashire Challenge Trophy 2nd Round |
| Ashton Athletic v Lancaster City (19:45) |
| Fulwood Amateurs v AFC Fylde (19:45) |
| Longridge Town v Daisy Hill (19:45) |
| Prestwich Heys v Padiham (19:45) |
| Squires Gate v Nelson (19:45) |
| Tuesday 18th November 2025 Liverpool Senior Cup Preliminary Round |
|
| MSB Woolton v Bootle (19:45) | |
| Played at Bootle | |
| Tuesday 18th November 2025 Manchester Premier Cup Preliminary Round |
| Ashton United v Chadderton (19:45) |
| Radcliffe v Irlam (19:45) |
| Wednesday 19th November 2025 Lancashire Challenge Trophy 2nd Round |
| West Didsbury & Chorlton v Clitheroe (19:45) |
| Garstang v Wythenshawe (20:00) |
