| Saturday 22nd February 2025 | Premier Division | ||
| 14:00 |  Cheadle Town v Glossop North End  | The Ground Up Solutions Stadium | |
| 15:00 |  Abbey Hey v Squires Gate  | The Abbey Stadium | |
| 15:00 |  AFC Liverpool v Prestwich Heys  | The Marine Travel Arena | |
| 15:00 |  Barnoldswick Town v Stockport Town  | Silentnight Stadium | |
| 15:00 |  FC St Helens v Padiham  | SMS PRO SOCCER PARK | |
| 15:00 |  Irlam v Burscough  | The Silver St Stadium | |
| 15:00 |  Litherland REMYCA v Charnock Richard  | Litherland Sports Park | |
| 15:00 |  South Liverpool v Bury  | Jericho Lane | |
| 15:00 |  West Didsbury & Chorlton v Pilkington  | Step Places Stadium | |
| 16:00 |  Chadderton v Longridge Town  | Vestacare Stadium | |
| Played at Avro | |||
| 18:00 |  FC Isle of Man v Colne  | The Bowl | |
| Saturday 22nd February 2025 | First Division North | ||
| 14:00 |  Ashton Athletic v Holker Old Boys  | Brocstedes Park | |
| 15:00 |  AFC Blackpool v Ashton Town  | Mechanics Ground | |
| 15:00 |  Atherton LR v Nelson  | Crilly Park | |
| 15:00 |  Bacup Borough v Droylsden  | Brian Boys West View Stadium | |
| 15:00 |  Route One Rovers v Euxton Villa  | Marley Stadium | |
| Saturday 22nd February 2025 | First Division South | ||
| 15:00 |  Abbey Hulton United v Allscott Heath  | Drayton Beaumont Park | |
| 15:00 |  Barnton v Ashville  | The Creative Hut Stadium | |
| 15:00 |  Cammell Laird 1907 v Wolverhampton Sporting Community  | KRCT LTD STADIUM | |
| 15:00 |  Cheadle Heath Nomads v Sandbach United  | Ideal Building Systems Stadium | |
| 15:00 |  Market Drayton Town v Stockport Georgians  | Greenfields Sports Ground | |
| 15:00 |  Stafford Town v Foley Meir  | Evans Park | |
| Tuesday 25th February 2025 | Premier Division | ||
| 19:45 | Longridge Town v Stockport Town | Longridge Town FC | |
| 19:45 | Padiham v Colne | Ruby Civil Arena | |
| Tuesday 25th February 2025 | First Division South | ||
| 20:00 | Stafford Town v Ashville | Evans Park | |
| Wednesday 26th February 2025 | Premier Division | ||
| 19:45 | Litherland REMYCA v West Didsbury & Chorlton | Litherland Sports Park | |
| Thursday 27th February 2025 | Liverpool Senior Cup QF | ||
| 20:00 |  Lower Breck v Prescot Cables  | Anfield Sports Community Centre | |
| Friday 28th February 2025 | Premier Division | ||
| 19:45 | Chadderton v Irlam | Vestacare Stadium | |
| Played at Avro | |||
| 19:45 |  Ramsbottom United v FC St Helens | Harry Williams Riverside Stadium | |
| Friday 28th February 2025 | First Division North | ||
| 19:45 |  Daisy Hill v Atherton LR | The Plumb Factory Stadium | |
| 19:45 | Euxton Villa v Skelmersdale United  | Jim Fowler Memorial Ground | |
| Saturday 1st March 2025 | Premier Division | ||
| 13:30 | Burscough v FC Isle of Man | The Community Ground | |
| 13:45 | Stockport Town v Cheadle Town | Stockport Sports Village | |
| 15:00 | Bury v Litherland REMYCA | Gigg Lane | |
| 15:00 | Colne v Charnock Richard | Haffners Stadium | |
| 15:00 | Longridge Town v Lower Breck | Longridge Town FC | |
| 15:00 | Padiham v AFC Liverpool | Ruby Civil Arena | |
| 15:00 | Pilkington v Barnoldswick Town | PSD Stadium | |
| 15:00 | Squires Gate v South Liverpool | The Brian Addison Stadium | |
| 19:30 | Glossop North End v West Didsbury & Chorlton | The Asgard Engineering Stadium | |
| Saturday 1st March 2025 | First Division North | ||
| 15:00 | Ashton Town v Route One Rovers | The Bartons Group Stadium | |
| 15:00 |  Garstang v Thornton Cleveleys  | The Riverside | |
| 15:00 |  Maghull v Holker Old Boys | DT Hughes Community Stadium | |
| 15:00 |  Maine Road v Ashton Athletic | Brantingham Road | |
| 15:00 |  Steeton v Nelson | Marley Stadium | |
| Saturday 1st March 2025 | First Division South | ||
| 11:00 | Stockport Georgians v Sandbach United | Cromley Road | |
| 15:00 | Abbey Hulton United v Cammell Laird 1907 | Drayton Beaumont Park | |
| 15:00 | Allscott Heath v Alsager Town  | The Giant Stadium | |
| 15:00 | Market Drayton Town v Ashville | Greenfields Sports Ground | |
| 15:00 |  Shawbury United v Barnton | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Stafford Town v Runcorn Town  | Evans Park | |
| 15:00 |  Winsford United v Eccleshall  | Barton Stadium | |
| 16:45 |  New Mills v Cheadle Heath Nomads | Church Lane | |
| Sunday 2nd March 2025 | Premier Division | ||
| 11:30 | Abbey Hey v Prestwich Heys | The Abbey Stadium | |
| Sunday 2nd March 2025 | First Division North | ||
| 14:30 | Droylsden v Darwen FC  | The Butchers Arms | |
| Tuesday 4th March 2025 | Premier Division | ||
| 19:45 | Ramsbottom United v Padiham | Harry Williams Riverside Stadium | |
| Thursday 6th March 2025 | Premier Division | ||
| 20:00 | Lower Breck v West Didsbury & Chorlton | Anfield Sports Community Centre | |
| Friday 7th March 2025 | Premier Division | ||
| 19:45 | Chadderton v South Liverpool | Vestacare Stadium | |
| Played at Avro | |||
| Saturday 8th March 2025 | Premier Division | ||
| 13:00 | Charnock Richard v Ramsbottom United | Mossie Park | |
| 13:00 | Lower Breck v FC St Helens | Anfield Sports Community Centre | |
| 15:00 | AFC Liverpool v Longridge Town | The Marine Travel Arena | |
| 15:00 | Bury v Barnoldswick Town | Gigg Lane | |
| 15:00 | Cheadle Town v West Didsbury & Chorlton | The Ground Up Solutions Stadium | |
| 15:00 | Glossop North End v Abbey Hey | The Asgard Engineering Stadium | |
| 15:00 | Irlam v Colne | The Silver St Stadium | |
| 15:00 | Litherland REMYCA v Padiham | Litherland Sports Park | |
| 15:00 | Prestwich Heys v Burscough | Adie Moran Park | |
| 15:00 | Stockport Town v Pilkington | Stockport Sports Village | |
| 18:00 | FC Isle of Man v Squires Gate | The Bowl | |
| Saturday 8th March 2025 | First Division North | ||
| 15:00 | Ashton Athletic v Bacup Borough | Brocstedes Park | |
| 15:00 | Ashton Town v Steeton | The Bartons Group Stadium | |
| 15:00 | Droylsden v Daisy Hill | The Butchers Arms | |
| 15:00 | Garstang v Euxton Villa | The Riverside | |
| 15:00 | Holker Old Boys v Atherton LR | The Handmark Engineering Stadium | |
| 15:00 | Maghull v AFC Blackpool | DT Hughes Community Stadium | |
| Saturday 8th March 2025 | First Division South | ||
| 15:00 | Ashville v Stockport Georgians | Ray Parker Stadium | |
| 15:00 | Barnton v New Mills | The Creative Hut Stadium | |
| 15:00 | Eccleshall v Cammell Laird 1907 | Stoke Signage Stadium | |
| 15:00 | Foley Meir v Market Drayton Town | Trentham Foods Stadium | |
| 15:00 | Runcorn Town v Abbey Hulton United | Viridor Community Stadium | |
| 15:00 | Stafford Town v Alsager Town | Evans Park | |
| Tuesday 11th March 2025 | Premier Division | ||
| 19:45 | Charnock Richard v Glossop North End | Mossie Park | |
| Tuesday 11th March 2025 | Staffordshire Senior Cup QF | ||
| 19:45 | Stafford Town v Chasetown  | Evans Park | |
| Wednesday 12th March 2025 | First Division North | ||
| 19:45 | AFC Blackpool v Ashton Athletic | Mechanics Ground | |
| Wednesday 12th March 2025 | Lancashire Challenge Trophy SF | ||
| 20:00 | Bacup Borough v Padiham | Brian Boys West View Stadium | |
| Thursday 13th March 2025 | Premier Division | ||
| 20:00 | Lower Breck v South Liverpool | Anfield Sports Community Centre | |
| Saturday 15th March 2025 | The Edward Case Cup SF | ||
| 15:00 | Holker Old Boys v Atherton LR | The Handmark Engineering Stadium | |
| 15:00 | Stafford Town v Ashville | Evans Park | |
| Saturday 15th March 2025 | Premier Division | ||
| 15:00 | AFC Liverpool v Lower Breck | The Marine Travel Arena | |
| 15:00 | Barnoldswick Town v Abbey Hey | Silentnight Stadium | |
| 15:00 | Burscough v Colne | The Community Ground | |
| 15:00 | Cheadle Town v Charnock Richard | The Ground Up Solutions Stadium | |
| 15:00 | FC St Helens v Bury | SMS PRO SOCCER PARK | |
| 15:00 | Irlam v Longridge Town | The Silver St Stadium | |
| 15:00 | Ramsbottom United v Litherland REMYCA | Harry Williams Riverside Stadium | |
| 15:00 | South Liverpool v Glossop North End | Jericho Lane | |
| 15:00 | West Didsbury & Chorlton v Padiham | Step Places Stadium | |
| 18:00 | FC Isle of Man v Pilkington | The Bowl | |
| Saturday 15th March 2025 | First Division North | ||
| 15:00 | Daisy Hill v AFC Blackpool | The Plumb Factory Stadium | |
| Saturday 15th March 2025 | First Division South | ||
| 15:00 | Cammell Laird 1907 v Barnton | KRCT LTD STADIUM | |
| 15:00 | Foley Meir v Stockport Georgians | Trentham Foods Stadium | |
| Saturday 22nd February 2025 Premier Division |
|
| Cheadle Town v Glossop North End (14:00) | |
| Abbey Hey v Squires Gate (15:00) | |
| AFC Liverpool v Prestwich Heys (15:00) | |
| Barnoldswick Town v Stockport Town (15:00) | |
| FC St Helens v Padiham (15:00) | |
| Irlam v Burscough (15:00) | |
| Litherland REMYCA v Charnock Richard (15:00) | |
| South Liverpool v Bury (15:00) | |
| West Didsbury & Chorlton v Pilkington (15:00) | |
| Chadderton v Longridge Town (16:00) | |
| Played at Avro | |
| FC Isle of Man v Colne (18:00) | |
| Saturday 22nd February 2025 First Division North |
| Ashton Athletic v Holker Old Boys (14:00) |
| AFC Blackpool v Ashton Town (15:00) |
| Atherton LR v Nelson (15:00) |
| Bacup Borough v Droylsden (15:00) |
| Route One Rovers v Euxton Villa (15:00) |
| Saturday 22nd February 2025 First Division South |
| Abbey Hulton United v Allscott Heath (15:00) |
| Barnton v Ashville (15:00) |
| Cammell Laird 1907 v Wolverhampton Sporting Community (15:00) |
| Cheadle Heath Nomads v Sandbach United (15:00) |
| Market Drayton Town v Stockport Georgians (15:00) |
| Stafford Town v Foley Meir (15:00) |
| Tuesday 25th February 2025 Premier Division |
| Longridge Town v Stockport Town (19:45) |
| Padiham v Colne (19:45) |
| Tuesday 25th February 2025 First Division South |
| Stafford Town v Ashville (20:00) |
| Wednesday 26th February 2025 Premier Division |
| Litherland REMYCA v West Didsbury & Chorlton (19:45) |
| Thursday 27th February 2025 Liverpool Senior Cup Quarter Finals |
| Lower Breck v Prescot Cables (20:00) |
| Friday 28th February 2025 Premier Division |
|
| Chadderton v Irlam (19:45) | |
| Played at Avro | |
| Ramsbottom United v FC St Helens (19:45) | |
| Friday 28th February 2025 First Division North |
| Daisy Hill v Atherton LR (19:45) |
| Euxton Villa v Skelmersdale United (19:45) |
| Saturday 1st March 2025 Premier Division |
| Burscough v FC Isle of Man (13:30) |
| Stockport Town v Cheadle Town (13:45) |
| Bury v Litherland REMYCA (15:00) |
| Colne v Charnock Richard (15:00) |
| Longridge Town v Lower Breck (15:00) |
| Padiham v AFC Liverpool (15:00) |
| Pilkington v Barnoldswick Town (15:00) |
| Squires Gate v South Liverpool (15:00) |
| Glossop North End v West Didsbury & Chorlton (19:30) |
| Saturday 1st March 2025 First Division North |
| Ashton Town v Route One Rovers (15:00) |
| Garstang v Thornton Cleveleys (15:00) |
| Maghull v Holker Old Boys (15:00) |
| Maine Road v Ashton Athletic (15:00) |
| Steeton v Nelson (15:00) |
| Saturday 1st March 2025 First Division South |
| Stockport Georgians v Sandbach United (11:00) |
| Abbey Hulton United v Cammell Laird 1907 (15:00) |
| Allscott Heath v Alsager Town (15:00) |
| Market Drayton Town v Ashville (15:00) |
| Shawbury United v Barnton (15:00) |
| Stafford Town v Runcorn Town (15:00) |
| Winsford United v Eccleshall (15:00) |
| New Mills v Cheadle Heath Nomads (16:45) |
| Sunday 2nd March 2025 Premier Division |
| Abbey Hey v Prestwich Heys (11:30) |
| Sunday 2nd March 2025 First Division North |
| Droylsden v Darwen FC (14:30) |
| Tuesday 4th March 2025 Premier Division |
| Ramsbottom United v Padiham (19:45) |
| Thursday 6th March 2025 Premier Division |
| Lower Breck v West Didsbury & Chorlton (20:00) |
| Friday 7th March 2025 Premier Division |
|
| Chadderton v South Liverpool (19:45) | |
| Played at Avro | |
| Saturday 8th March 2025 Premier Division |
| Charnock Richard v Ramsbottom United (13:00) |
| Lower Breck v FC St Helens (13:00) |
| AFC Liverpool v Longridge Town (15:00) |
| Bury v Barnoldswick Town (15:00) |
| Cheadle Town v West Didsbury & Chorlton (15:00) |
| Glossop North End v Abbey Hey (15:00) |
| Irlam v Colne (15:00) |
| Litherland REMYCA v Padiham (15:00) |
| Prestwich Heys v Burscough (15:00) |
| Stockport Town v Pilkington (15:00) |
| FC Isle of Man v Squires Gate (18:00) |
| Saturday 8th March 2025 First Division North |
| Ashton Athletic v Bacup Borough (15:00) |
| Ashton Town v Steeton (15:00) |
| Droylsden v Daisy Hill (15:00) |
| Garstang v Euxton Villa (15:00) |
| Holker Old Boys v Atherton LR (15:00) |
| Maghull v AFC Blackpool (15:00) |
| Saturday 8th March 2025 First Division South |
| Ashville v Stockport Georgians (15:00) |
| Barnton v New Mills (15:00) |
| Eccleshall v Cammell Laird 1907 (15:00) |
| Foley Meir v Market Drayton Town (15:00) |
| Runcorn Town v Abbey Hulton United (15:00) |
| Stafford Town v Alsager Town (15:00) |
| Tuesday 11th March 2025 Premier Division |
| Charnock Richard v Glossop North End (19:45) |
| Tuesday 11th March 2025 Staffordshire Senior Cup Quarter Finals |
| Stafford Town v Chasetown (19:45) |
| Wednesday 12th March 2025 First Division North |
| AFC Blackpool v Ashton Athletic (19:45) |
| Wednesday 12th March 2025 Lancashire Challenge Trophy Semi Finals |
| Bacup Borough v Padiham (20:00) |
| Thursday 13th March 2025 Premier Division |
| Lower Breck v South Liverpool (20:00) |
| Saturday 15th March 2025 The Edward Case Cup Semi Finals |
| Holker Old Boys v Atherton LR (15:00) |
| Stafford Town v Ashville (15:00) |
| Saturday 15th March 2025 Premier Division |
| AFC Liverpool v Lower Breck (15:00) |
| Barnoldswick Town v Abbey Hey (15:00) |
| Burscough v Colne (15:00) |
| Cheadle Town v Charnock Richard (15:00) |
| FC St Helens v Bury (15:00) |
| Irlam v Longridge Town (15:00) |
| Ramsbottom United v Litherland REMYCA (15:00) |
| South Liverpool v Glossop North End (15:00) |
| West Didsbury & Chorlton v Padiham (15:00) |
| FC Isle of Man v Pilkington (18:00) |
| Saturday 15th March 2025 First Division North |
| Daisy Hill v AFC Blackpool (15:00) |
| Saturday 15th March 2025 First Division South |
| Cammell Laird 1907 v Barnton (15:00) |
| Foley Meir v Stockport Georgians (15:00) |
