| Monday 15th September 2025 | First Division South | ||
| 19:45 |  Cheadle Heath Nomads v Runcorn Town  | Ideal Building Systems Stadium | |
| Tuesday 16th September 2025 | Premier Division | ||
| 19:45 |  AFC Liverpool v FC Isle of Man  | Berry Street Garage Stadium | |
| 19:45 |  Atherton LR v Litherland REMYCA  | Crilly Park | |
| 19:45 |  Chadderton v Euxton Villa  | Emplas Commercial North Stadium | |
| 19:45 |  Charnock Richard v Padiham  | Mossie Park | |
| 19:45 |  City of Liverpool v Pilkington  | The Community Ground | |
| 19:45 |  FC St Helens v Wythenshawe  | SMS PRO SOCCER PARK | |
| 19:45 |  Glossop North End v Prestwich Heys  | The Asgard Engineering Stadium | |
| 19:45 |  Irlam v West Didsbury & Chorlton  | The Silver St Stadium | |
| 19:45 |  Longridge Town v Barnoldswick Town  | Inglewhite Road | |
| 19:45 |  Ramsbottom United v Burscough  | Harry Williams Riverside Stadium | |
| Tuesday 16th September 2025 | First Division South | ||
| 19:45 |  Allscott Heath v Shawbury United  | The Giant Stadium | |
| 19:45 |  Alsager Town v Eccleshall  | Wood Park | |
| 19:45 |  Haughmond v Wolverhampton Casuals  | Sundorne Sports Village | |
| 19:45 |  New Mills v Stockport Georgians  | Church Lane | |
| 19:45 |  Sandbach United v Market Drayton Town  | Sandbach Community Football Centre | |
| 19:45 |  Wolverhampton Sporting Community v Foley Meir  | Pride Park | |
| 20:00 |  Stafford Town v Telford Town  | Evans Park | |
| Tuesday 16th September 2025 | Lancashire Challenge Trophy 1st Rnd | ||
| 19:45 |  Colne v Nelson  | Haffners Eats Stadium | |
| Wednesday 17th September 2025 | Premier Division | ||
| 19:45 |  South Liverpool v Abbey Hey  | Jericho Lane | |
| Wednesday 17th September 2025 | First Division South | ||
| 19:45 |  Barnton v Ashville  | The Creative Hut Stadium | |
| Saturday 20th September 2025 | The Macron Cup 1st Rnd | ||
| 15:00 | Abbey Hey v Stockport Georgians | The Abbey Stadium | |
| Saturday 20th September 2025 | Premier Division | ||
| 15:00 | Atherton LR v FC St Helens | Crilly Park | |
| 15:00 | Litherland REMYCA v South Liverpool | Litherland Sports Park | |
| 15:00 | Pilkington v FC Isle of Man | PSD Stadium | |
| 15:00 | West Didsbury & Chorlton v Glossop North End | Step Places Stadium | |
| Saturday 20th September 2025 | First Division North | ||
| 15:00 |  Ashton Athletic v MSB Woolton  | Brocstedes Park | |
| 15:00 |  Ashton Town v AFC Blackpool  | The Bartons Group Stadium | |
| 15:00 |  Maine Road v Steeton  | Brantingham Road | |
| Saturday 20th September 2025 | First Division South | ||
| 15:00 |  Cammell Laird 1907 v Cheadle Heath Nomads | The OWS Engineering Ltd Stadium | |
| 15:00 | Market Drayton Town v Shawbury United | Greenfields Sports Ground | |
| 15:00 | Wolverhampton Casuals v Telford Town | Brinsford Stadium | |
| Sunday 21st September 2025 | The Isuzu FA Vase 2nd Qual Rnd | ||
| 15:00 |  Campion v Padiham | 1st Glass Stadium | |
| Tuesday 23rd September 2025 | Premier Division | ||
| 19:45 | Barnoldswick Town v Stockport Town  | Silentnight Stadium | |
| 19:45 | Chadderton v West Didsbury & Chorlton | Emplas Commercial North Stadium | |
| 19:45 |  Cheadle Town v Glossop North End | The Ground Up Solutions Stadium | |
| 19:45 | City of Liverpool v FC St Helens | The Community Ground | |
| 19:45 | Irlam v Wythenshawe | The Silver St Stadium | |
| 19:45 | Longridge Town v Atherton LR | Inglewhite Road | |
| 19:45 | Padiham v Burscough | Ruby Civil Arena | |
| 19:45 | Prestwich Heys v Charnock Richard | Adie Moran Park | |
| 20:00 | Euxton Villa v Ramsbottom United | Jim Fowler Memorial Ground | |
| Tuesday 23rd September 2025 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 |  Nantwich Town v Cammell Laird 1907 | The Weaver Stadium | |
| Wednesday 24th September 2025 | Premier Division | ||
| 19:45 | Pilkington v Litherland REMYCA | PSD Stadium | |
| Wednesday 24th September 2025 | First Division North | ||
| 19:45 | MSB Woolton v Bacup Borough  | Jericho Lane | |
| Friday 26th September 2025 | The Macron Cup 1st Rnd | ||
| 19:45 | AFC Liverpool v South Liverpool | Berry Street Garage Stadium | |
| 19:45 | Ashton Athletic v FC St Helens | Brocstedes Park | |
| 19:45 | Ashton Town v City of Liverpool | The Bartons Group Stadium | |
| 19:45 |  Droylsden v Maine Road | The Butchers Arms | |
| 20:00 | Euxton Villa v Holker Old Boys  | Jim Fowler Memorial Ground | |
| Tuesday 30th September 2025 | Premier Division | ||
| 19:45 | Chadderton v Burscough | Emplas Commercial North Stadium | |
| 19:45 | City of Liverpool v Longridge Town | The Community Ground | |
| 19:45 | Glossop North End v Atherton LR | The Asgard Engineering Stadium | |
| Tuesday 30th September 2025 | Staffordshire Senior Cup 1st Rnd | ||
| 19:45 | Wolverhampton Casuals v Wolverhampton Sporting Community | Brinsford Stadium | |
| Wednesday 1st October 2025 | Premier Division | ||
| 19:45 | West Didsbury & Chorlton v AFC Liverpool | Step Places Stadium | |
| Wednesday 1st October 2025 | First Division North | ||
| 20:00 | Bacup Borough v Colne | Brian Boys West View Stadium | |
| Saturday 4th October 2025 | Premier Division | ||
| 15:00 | Abbey Hey v Euxton Villa | The Abbey Stadium | |
| 15:00 | Atherton LR v AFC Liverpool | Crilly Park | |
| 15:00 | Burscough v City of Liverpool | The Community Ground | |
| 15:00 | Charnock Richard v FC St Helens | Mossie Park | |
| 15:00 | Glossop North End v Chadderton | The Asgard Engineering Stadium | |
| 15:00 | Litherland REMYCA v Padiham | Litherland Sports Park | |
| 15:00 | Pilkington v Cheadle Town | PSD Stadium | |
| 15:00 | Ramsbottom United v Prestwich Heys | Harry Williams Riverside Stadium | |
| 15:00 | Stockport Town v Irlam | Stockport Sports Village | |
| 15:00 | West Didsbury & Chorlton v Longridge Town | Step Places Stadium | |
| 15:00 | Wythenshawe v South Liverpool | Avensure Community Stadium | |
| 18:00 | FC Isle of Man v Barnoldswick Town | The Bowl | |
| Saturday 4th October 2025 | First Division North | ||
| 15:00 | Ashton Athletic v AFC Blackpool | Brocstedes Park | |
| 15:00 |  Daisy Hill v Colne | The Ginge Power Stadium | |
| 15:00 |  Darwen FC v Maghull  | Multevo Group Anchor Ground | |
| 15:00 |  Garstang v Ashton Town | The Riverside | |
| 15:00 | Maine Road v Bacup Borough | Brantingham Road | |
| 15:00 | MSB Woolton v Steeton | Jericho Lane | |
| 15:00 | Nelson v Fulwood Amateurs  | The Daisy Arena Little Wembley | |
| 15:00 |  Squires Gate v Holker Old Boys | The Skiddle Community Stadium | |
| 15:00 |  Thornton Cleveleys v Droylsden | Gamble Road | |
| Saturday 4th October 2025 | First Division South | ||
| 15:00 | Allscott Heath v Haughmond | The Giant Stadium | |
| 15:00 | Ashville v Cheadle Heath Nomads | Ray Parker Stadium | |
| 15:00 | Eccleshall v Telford Town | Stoke Signage Stadium | |
| 15:00 | Market Drayton Town v Stafford Town | Greenfields Sports Ground | |
| 15:00 | New Mills v Cammell Laird 1907 | Church Lane | |
| 15:00 | Runcorn Town v Foley Meir | Viridor Community Stadium | |
| 15:00 | Shawbury United v Barnton | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Stockport Georgians v Sandbach United | Cromley Road | |
| 15:00 | Wolverhampton Sporting Community v Alsager Town | Pride Park | |
| Monday 15th September 2025 First Division South |
| Cheadle Heath Nomads v Runcorn Town (19:45) |
| Tuesday 16th September 2025 Premier Division |
| AFC Liverpool v FC Isle of Man (19:45) |
| Atherton LR v Litherland REMYCA (19:45) |
| Chadderton v Euxton Villa (19:45) |
| Charnock Richard v Padiham (19:45) |
| City of Liverpool v Pilkington (19:45) |
| FC St Helens v Wythenshawe (19:45) |
| Glossop North End v Prestwich Heys (19:45) |
| Irlam v West Didsbury & Chorlton (19:45) |
| Longridge Town v Barnoldswick Town (19:45) |
| Ramsbottom United v Burscough (19:45) |
| Tuesday 16th September 2025 First Division South |
| Allscott Heath v Shawbury United (19:45) |
| Alsager Town v Eccleshall (19:45) |
| Haughmond v Wolverhampton Casuals (19:45) |
| New Mills v Stockport Georgians (19:45) |
| Sandbach United v Market Drayton Town (19:45) |
| Wolverhampton Sporting Community v Foley Meir (19:45) |
| Stafford Town v Telford Town (20:00) |
| Tuesday 16th September 2025 Lancashire Challenge Trophy 1st Round |
| Colne v Nelson (19:45) |
| Wednesday 17th September 2025 Premier Division |
| South Liverpool v Abbey Hey (19:45) |
| Wednesday 17th September 2025 First Division South |
| Barnton v Ashville (19:45) |
| Saturday 20th September 2025 The Macron Cup 1st Round |
| Abbey Hey v Stockport Georgians (15:00) |
| Saturday 20th September 2025 Premier Division |
| Atherton LR v FC St Helens (15:00) |
| Litherland REMYCA v South Liverpool (15:00) |
| Pilkington v FC Isle of Man (15:00) |
| West Didsbury & Chorlton v Glossop North End (15:00) |
| Saturday 20th September 2025 First Division North |
| Ashton Athletic v MSB Woolton (15:00) |
| Ashton Town v AFC Blackpool (15:00) |
| Maine Road v Steeton (15:00) |
| Saturday 20th September 2025 First Division South |
| Cammell Laird 1907 v Cheadle Heath Nomads (15:00) |
| Market Drayton Town v Shawbury United (15:00) |
| Wolverhampton Casuals v Telford Town (15:00) |
| Sunday 21st September 2025 The Isuzu FA Vase 2nd Qualifying Round |
| Campion v Padiham (15:00) |
| Tuesday 23rd September 2025 Premier Division |
| Barnoldswick Town v Stockport Town (19:45) |
| Chadderton v West Didsbury & Chorlton (19:45) |
| Cheadle Town v Glossop North End (19:45) |
| City of Liverpool v FC St Helens (19:45) |
| Irlam v Wythenshawe (19:45) |
| Longridge Town v Atherton LR (19:45) |
| Padiham v Burscough (19:45) |
| Prestwich Heys v Charnock Richard (19:45) |
| Euxton Villa v Ramsbottom United (20:00) |
| Tuesday 23rd September 2025 Cheshire Senior Cup 1st Round |
| Nantwich Town v Cammell Laird 1907 (19:45) |
| Wednesday 24th September 2025 Premier Division |
| Pilkington v Litherland REMYCA (19:45) |
| Wednesday 24th September 2025 First Division North |
| MSB Woolton v Bacup Borough (19:45) |
| Friday 26th September 2025 The Macron Cup 1st Round |
| AFC Liverpool v South Liverpool (19:45) |
| Ashton Athletic v FC St Helens (19:45) |
| Ashton Town v City of Liverpool (19:45) |
| Droylsden v Maine Road (19:45) |
| Euxton Villa v Holker Old Boys (20:00) |
| Saturday 27th September 2025 The Macron Cup 1st Round |
| Allscott Heath v Alsager Town (15:00) |
| Ashville v Foley Meir (15:00) |
| Bacup Borough v AFC Blackpool (15:00) |
| Cheadle Town v Glossop North End (15:00) |
| Daisy Hill v Burscough (15:00) |
| Darwen FC v Garstang (15:00) |
| Eccleshall v Market Drayton Town (15:00) |
| Fulwood Amateurs v Nelson (15:00) |
| Irlam v Chadderton (15:00) |
| Litherland REMYCA v MSB Woolton (15:00) |
| Longridge Town v Barnoldswick Town (15:00) |
| Pilkington v Atherton LR (15:00) |
| Runcorn Town v Barnton (15:00) |
| Sandbach United v Haughmond (15:00) |
| Shawbury United v Wolverhampton Casuals (15:00) |
| Squires Gate v Colne (15:00) |
| Stafford Town v Cammell Laird 1907 (15:00) |
| Stockport Town v Prestwich Heys (15:00) |
| Telford Town v Wolverhampton Sporting Community (15:00) |
| Thornton Cleveleys v Steeton (15:00) |
| West Didsbury & Chorlton v Cheadle Heath Nomads (15:00) |
| Wythenshawe v New Mills (15:00) |
| Tuesday 30th September 2025 Premier Division |
| Chadderton v Burscough (19:45) |
| City of Liverpool v Longridge Town (19:45) |
| Glossop North End v Atherton LR (19:45) |
| Tuesday 30th September 2025 Staffordshire Senior Cup 1st Round |
| Wolverhampton Casuals v Wolverhampton Sporting Community (19:45) |
| Wednesday 1st October 2025 Premier Division |
| West Didsbury & Chorlton v AFC Liverpool (19:45) |
| Wednesday 1st October 2025 First Division North |
| Bacup Borough v Colne (20:00) |
| Saturday 4th October 2025 Premier Division |
| Abbey Hey v Euxton Villa (15:00) |
| Atherton LR v AFC Liverpool (15:00) |
| Burscough v City of Liverpool (15:00) |
| Charnock Richard v FC St Helens (15:00) |
| Glossop North End v Chadderton (15:00) |
| Litherland REMYCA v Padiham (15:00) |
| Pilkington v Cheadle Town (15:00) |
| Ramsbottom United v Prestwich Heys (15:00) |
| Stockport Town v Irlam (15:00) |
| West Didsbury & Chorlton v Longridge Town (15:00) |
| Wythenshawe v South Liverpool (15:00) |
| FC Isle of Man v Barnoldswick Town (18:00) |
| Saturday 4th October 2025 First Division North |
| Ashton Athletic v AFC Blackpool (15:00) |
| Daisy Hill v Colne (15:00) |
| Darwen FC v Maghull (15:00) |
| Garstang v Ashton Town (15:00) |
| Maine Road v Bacup Borough (15:00) |
| MSB Woolton v Steeton (15:00) |
| Nelson v Fulwood Amateurs (15:00) |
| Squires Gate v Holker Old Boys (15:00) |
| Thornton Cleveleys v Droylsden (15:00) |
| Saturday 4th October 2025 First Division South |
| Allscott Heath v Haughmond (15:00) |
| Ashville v Cheadle Heath Nomads (15:00) |
| Eccleshall v Telford Town (15:00) |
| Market Drayton Town v Stafford Town (15:00) |
| New Mills v Cammell Laird 1907 (15:00) |
| Runcorn Town v Foley Meir (15:00) |
| Shawbury United v Barnton (15:00) |
| Stockport Georgians v Sandbach United (15:00) |
| Wolverhampton Sporting Community v Alsager Town (15:00) |
