| Saturday 26th July 2025 | Premier Division | ||
| 15:00 |  AFC Liverpool v Irlam  | Berry Street Garage Stadium | |
| 15:00 |  Burscough v Abbey Hey  | The Community Ground | |
| 15:00 |  Chadderton v Charnock Richard  | Emplas Commercial North Stadium | |
| 15:00 |  Cheadle Town v Barnoldswick Town  | The Ground Up Solutions Stadium | |
| 15:00 |  Euxton Villa v Prestwich Heys  | Jim Fowler Memorial Ground | |
| 15:00 |  Glossop North End v City of Liverpool  | The Asgard Engineering Stadium | |
| 15:00 |  Longridge Town v FC St Helens  | Inglewhite Road | |
| 15:00 |  Padiham v Wythenshawe  | Ruby Civil Arena | |
| 15:00 |  Ramsbottom United v Atherton LR  | Harry Williams Riverside Stadium | |
| 15:00 |  South Liverpool v Stockport Town  | Jericho Lane | |
| 15:00 |  West Didsbury & Chorlton v Pilkington  | Step Places Stadium | |
| 18:00 |  FC Isle of Man v Litherland REMYCA  | The Bowl | |
| Tuesday 29th July 2025 | Premier Division | ||
| 19:45 | Abbey Hey v Stockport Town | The Abbey Stadium | |
| 19:45 | Atherton LR v South Liverpool | Crilly Park | |
| 19:45 | Barnoldswick Town v Charnock Richard | Silentnight Stadium | |
| 19:45 | Burscough v AFC Liverpool | The Community Ground | |
| 19:45 | Cheadle Town v Ramsbottom United | The Ground Up Solutions Stadium | |
| 19:45 | FC St Helens v FC Isle of Man | SMS PRO SOCCER PARK | |
| 19:45 | Glossop North End v West Didsbury & Chorlton | The Asgard Engineering Stadium | |
| 19:45 | Irlam v Pilkington | The Silver St Stadium | |
| 19:45 | Prestwich Heys v Padiham | Adie Moran Park | |
| 19:45 | Wythenshawe v Chadderton | Hollyhedge Park Community Stadium | |
| 20:00 | Euxton Villa v Longridge Town | Jim Fowler Memorial Ground | |
| Wednesday 30th July 2025 | Premier Division | ||
| 19:45 | Litherland REMYCA v City of Liverpool | Litherland Sports Park | |
| Saturday 9th August 2025 | Premier Division | ||
| 15:00 | AFC Liverpool v Cheadle Town | Berry Street Garage Stadium | |
| 15:00 | Chadderton v South Liverpool | Emplas Commercial North Stadium | |
| 15:00 | Charnock Richard v Irlam | Mossie Park | |
| 15:00 | City of Liverpool v Atherton LR | DCBL Stadium | |
| 15:00 | Litherland REMYCA v Barnoldswick Town | Litherland Sports Park | |
| 15:00 | Longridge Town v Wythenshawe | Inglewhite Road | |
| 15:00 | Pilkington v Abbey Hey | PSD Stadium | |
| 15:00 | Prestwich Heys v Burscough | Adie Moran Park | |
| 15:00 | Ramsbottom United v FC St Helens | Harry Williams Riverside Stadium | |
| 15:00 | Stockport Town v Padiham | Stockport Sports Village | |
| 15:00 | West Didsbury & Chorlton v Euxton Villa | Step Places Stadium | |
| 18:00 | FC Isle of Man v Glossop North End | The Bowl | |
| Monday 11th August 2025 | Premier Division | ||
| 19:45 | Stockport Town v Prestwich Heys | Stockport Sports Village | |
| Tuesday 12th August 2025 | Premier Division | ||
| 19:45 | Abbey Hey v Ramsbottom United | The Abbey Stadium | |
| 19:45 | AFC Liverpool v FC St Helens | Berry Street Garage Stadium | |
| 19:45 | Barnoldswick Town v Chadderton | Silentnight Stadium | |
| 19:45 | Burscough v Longridge Town | The Community Ground | |
| 19:45 | Charnock Richard v Pilkington | Mossie Park | |
| 19:45 | Cheadle Town v City of Liverpool | The Ground Up Solutions Stadium | |
| 19:45 | Glossop North End v Wythenshawe | The Asgard Engineering Stadium | |
| 19:45 | Irlam v FC Isle of Man | The Silver St Stadium | |
| 19:45 | Padiham v Euxton Villa | Ruby Civil Arena | |
| Wednesday 13th August 2025 | Premier Division | ||
| 19:45 | South Liverpool v Litherland REMYCA | Jericho Lane | |
| 19:45 | West Didsbury & Chorlton v Atherton LR | Step Places Stadium | |
| Monday 25th August 2025 | Premier Division | ||
| 15:00 | Abbey Hey v Glossop North End | The Abbey Stadium | |
| 15:00 | Atherton LR v Stockport Town | Crilly Park | |
| 15:00 | Barnoldswick Town v Prestwich Heys | Silentnight Stadium | |
| 15:00 | Cheadle Town v Irlam | The Ground Up Solutions Stadium | |
| 15:00 | City of Liverpool v West Didsbury & Chorlton | DCBL Stadium | |
| 15:00 | Euxton Villa v Litherland REMYCA | Jim Fowler Memorial Ground | |
| 15:00 | FC St Helens v Chadderton | SMS PRO SOCCER PARK | |
| 15:00 | Longridge Town v Charnock Richard | Inglewhite Road | |
| 15:00 | Padiham v Ramsbottom United | Ruby Civil Arena | |
| 15:00 | Pilkington v AFC Liverpool | PSD Stadium | |
| 15:00 | South Liverpool v Burscough | Jericho Lane | |
| 15:00 | Wythenshawe v FC Isle of Man | Hollyhedge Park Community Stadium | |
| Saturday 30th August 2025 | Premier Division | ||
| 15:00 | AFC Liverpool v West Didsbury & Chorlton | Berry Street Garage Stadium | |
| 15:00 | Atherton LR v FC St Helens | Crilly Park | |
| 15:00 | Chadderton v Burscough | Emplas Commercial North Stadium | |
| 15:00 | Charnock Richard v Abbey Hey | Mossie Park | |
| 15:00 | City of Liverpool v Longridge Town | DCBL Stadium | |
| 15:00 | Glossop North End v South Liverpool | The Asgard Engineering Stadium | |
| 15:00 | Litherland REMYCA v Irlam | Litherland Sports Park | |
| 15:00 | Pilkington v Barnoldswick Town | PSD Stadium | |
| 15:00 | Prestwich Heys v Cheadle Town | Adie Moran Park | |
| 15:00 | Ramsbottom United v Wythenshawe | Harry Williams Riverside Stadium | |
| 15:00 | Stockport Town v Euxton Villa | Stockport Sports Village | |
| 18:00 | FC Isle of Man v Padiham | The Bowl | |
| Saturday 26th July 2025 Premier Division |
| AFC Liverpool v Irlam (15:00) |
| Burscough v Abbey Hey (15:00) |
| Chadderton v Charnock Richard (15:00) |
| Cheadle Town v Barnoldswick Town (15:00) |
| Euxton Villa v Prestwich Heys (15:00) |
| Glossop North End v City of Liverpool (15:00) |
| Longridge Town v FC St Helens (15:00) |
| Padiham v Wythenshawe (15:00) |
| Ramsbottom United v Atherton LR (15:00) |
| South Liverpool v Stockport Town (15:00) |
| West Didsbury & Chorlton v Pilkington (15:00) |
| FC Isle of Man v Litherland REMYCA (18:00) |
| Tuesday 29th July 2025 Premier Division |
| Abbey Hey v Stockport Town (19:45) |
| Atherton LR v South Liverpool (19:45) |
| Barnoldswick Town v Charnock Richard (19:45) |
| Burscough v AFC Liverpool (19:45) |
| Cheadle Town v Ramsbottom United (19:45) |
| FC St Helens v FC Isle of Man (19:45) |
| Glossop North End v West Didsbury & Chorlton (19:45) |
| Irlam v Pilkington (19:45) |
| Prestwich Heys v Padiham (19:45) |
| Wythenshawe v Chadderton (19:45) |
| Euxton Villa v Longridge Town (20:00) |
| Wednesday 30th July 2025 Premier Division |
| Litherland REMYCA v City of Liverpool (19:45) |
| Saturday 9th August 2025 Premier Division |
| AFC Liverpool v Cheadle Town (15:00) |
| Chadderton v South Liverpool (15:00) |
| Charnock Richard v Irlam (15:00) |
| City of Liverpool v Atherton LR (15:00) |
| Litherland REMYCA v Barnoldswick Town (15:00) |
| Longridge Town v Wythenshawe (15:00) |
| Pilkington v Abbey Hey (15:00) |
| Prestwich Heys v Burscough (15:00) |
| Ramsbottom United v FC St Helens (15:00) |
| Stockport Town v Padiham (15:00) |
| West Didsbury & Chorlton v Euxton Villa (15:00) |
| FC Isle of Man v Glossop North End (18:00) |
| Monday 11th August 2025 Premier Division |
| Stockport Town v Prestwich Heys (19:45) |
| Tuesday 12th August 2025 Premier Division |
| Abbey Hey v Ramsbottom United (19:45) |
| AFC Liverpool v FC St Helens (19:45) |
| Barnoldswick Town v Chadderton (19:45) |
| Burscough v Longridge Town (19:45) |
| Charnock Richard v Pilkington (19:45) |
| Cheadle Town v City of Liverpool (19:45) |
| Glossop North End v Wythenshawe (19:45) |
| Irlam v FC Isle of Man (19:45) |
| Padiham v Euxton Villa (19:45) |
| Wednesday 13th August 2025 Premier Division |
| South Liverpool v Litherland REMYCA (19:45) |
| West Didsbury & Chorlton v Atherton LR (19:45) |
| Monday 25th August 2025 Premier Division |
| Abbey Hey v Glossop North End (15:00) |
| Atherton LR v Stockport Town (15:00) |
| Barnoldswick Town v Prestwich Heys (15:00) |
| Cheadle Town v Irlam (15:00) |
| City of Liverpool v West Didsbury & Chorlton (15:00) |
| Euxton Villa v Litherland REMYCA (15:00) |
| FC St Helens v Chadderton (15:00) |
| Longridge Town v Charnock Richard (15:00) |
| Padiham v Ramsbottom United (15:00) |
| Pilkington v AFC Liverpool (15:00) |
| South Liverpool v Burscough (15:00) |
| Wythenshawe v FC Isle of Man (15:00) |
| Saturday 30th August 2025 Premier Division |
| AFC Liverpool v West Didsbury & Chorlton (15:00) |
| Atherton LR v FC St Helens (15:00) |
| Chadderton v Burscough (15:00) |
| Charnock Richard v Abbey Hey (15:00) |
| City of Liverpool v Longridge Town (15:00) |
| Glossop North End v South Liverpool (15:00) |
| Litherland REMYCA v Irlam (15:00) |
| Pilkington v Barnoldswick Town (15:00) |
| Prestwich Heys v Cheadle Town (15:00) |
| Ramsbottom United v Wythenshawe (15:00) |
| Stockport Town v Euxton Villa (15:00) |
| FC Isle of Man v Padiham (18:00) |
