| Tue 21/10/25 | Wythenshawe v FC St Helens | 1-4 | | | | | | |
| Sat 25/10/25 | FC St Helens v Stockport Town | 1-1 | | | | | | |
| Tue 28/10/25 | Charnock Richard v FC St Helens | 2-2 | | | | | | |
| Sat 01/11/25 | Cheadle Town v FC St Helens | 0-3 | |  | | | | |
| Sat 08/11/25 | FC St Helens v Padiham | 1-1 | | | | | | |
| Tue 18/11/25 | Glossop North End v FC St Helens | 1-3 | | | |  | | |
| Fri 28/11/25 | FC St Helens v Litherland REMYCA | 1-0 | | | | | | |
| Tue 02/12/25 | FC St Helens v South Liverpool | 3-1 | | | | | | |
| Sat 06/12/25 | Stockport Town v FC St Helens | 0-4 | | | | | | |
| Sat 13/12/25 | Irlam v FC St Helens | 4-1 | | | | | | |
| Sat 20/12/25 | FC St Helens v Cheadle Town | 1-1 | | | | | | |
| Fri 26/12/25 | Pilkington v FC St Helens | 3-2 | | | | | | |
| Sat 17/01/26 | Padiham v FC St Helens | 2-1 | | | | | | |
| Tue 20/01/26 | FC St Helens v City of Liverpool | 1-0 | | | | | | |
| Sat 24/01/26 | FC St Helens v Barnoldswick Town | 5-0 |  | | | | | |
| Wed 28/01/26 | Litherland REMYCA v FC St Helens | 2-2 | | | | | | |
| Sat 31/01/26 | FC St Helens v Charnock Richard | 6-2 | | | | | | |
| Sat 21/02/26 | FC St Helens v Atherton LR | - | | | | | | |
| Tue 24/02/26 | FC St Helens v West Didsbury & Chorlton | 3-0 | | | | | | |
| Fri 27/02/26 | FC St Helens v Burscough | 1-0 | | | | | | |
| Tue 03/03/26 | FC St Helens v Euxton Villa | 0-0 | | | | | | |
| Sat 07/03/26 | West Didsbury & Chorlton v FC St Helens | 1-1 | | | | | | |
| Sat 14/03/26 | FC St Helens v Ramsbottom United | 1-2 | | | | | | |
| Sat 21/03/26 | FC St Helens v Longridge Town | 2-1 | | | | | | |
| Sat 11/04/26 | FC St Helens v Chadderton | 1-0 | | | | | | |
| Tue 14/04/26 | FC St Helens v AFC Liverpool | 0-2 | | | | | | |
| Sat 18/04/26 | FC St Helens v Abbey Hey * | 3-0 | | | | | | |
