| Sat 26/07/25 | FC Isle of Man v Litherland REMYCA | 0-0 | |  | | | | |
| Wed 30/07/25 | Litherland REMYCA v City of Liverpool | 2-0 | | | | | | |
| Sat 02/08/25 | Whitchurch Alport v Litherland REMYCA (CUP) | 3-0 | | | | | | |
| Sat 09/08/25 | Litherland REMYCA v Barnoldswick Town | 1-3 | | | | | | |
| Wed 13/08/25 | South Liverpool v Litherland REMYCA | 2-1 | | | | | | |
| Sat 16/08/25 | Burscough v Litherland REMYCA | 3-0 | | | | | | |
| Sat 23/08/25 | Litherland REMYCA v Rossington Main (CUP) | 2-2 | | | | | | |
| Mon 25/08/25 | Euxton Villa v Litherland REMYCA | 3-2 | | | | | | |
| Sat 30/08/25 | Litherland REMYCA v Irlam | 0-3 | | | |  | | |
| Sat 06/09/25 | Stockport Town v Litherland REMYCA | 1-0 | | |  | | | |
| Tue 09/09/25 | Longridge Town v Litherland REMYCA | 3-0 | | | | | | |
| Sat 13/09/25 | Litherland REMYCA v Glossop North End | 1-2 | | | | | | |
| Tue 16/09/25 | Atherton LR v Litherland REMYCA | 3-1 | | | | | | |
| Sat 20/09/25 | Litherland REMYCA v South Liverpool | 0-3 | | | | | | |
| Wed 24/09/25 | Pilkington v Litherland REMYCA | 1-0 | | | | | | |
| Sat 27/09/25 | Litherland REMYCA v MSB Woolton (CUP) | 2-2 | | | | | | |
| Wed 08/10/25 | West Didsbury & Chorlton v Litherland REMYCA | 3-0 | | | | | | |
| Sat 11/10/25 | Litherland REMYCA v FC Isle of Man | 1-3 | | | | | | |
| Wed 15/10/25 | Litherland REMYCA v Chadderton | 1-2 | | | | | | |
| Sat 18/10/25 | Padiham v Litherland REMYCA | 4-0 | | | | | | |
| Sat 25/10/25 | Litherland REMYCA v Wythenshawe | 1-2 | | | | | |  |
| Wed 29/10/25 | Litherland REMYCA v Padiham | 2-3 | | | | | | |
| Sat 01/11/25 | Charnock Richard v Litherland REMYCA | 3-0 | | | | | | |
| Sat 22/11/25 | Litherland REMYCA v Stockport Town | 0-6 | | | | | | |
