| Sat 27/07/24 | FC St Helens v Abbey Hey * | 3-0 | |  | | | | |
| Wed 31/07/24 | Cheadle Town v FC St Helens * | 1-3 | | | |  | | |
| Sun 04/08/24 | Emley v FC St Helens (CUP) | 1-0 | | | | | | |
| Sat 07/09/24 | FC St Helens v Litherland REMYCA * | 2-1 | | | | | | |
| Tue 24/09/24 | FC St Helens v West Didsbury & Chorlton * | 0-1 | | | | | | |
| Sat 05/10/24 | FC St Helens v AFC Liverpool | 3-2 | | | | | | |
| Tue 08/10/24 | FC St Helens v Litherland REMYCA (CUP) | 2-1 | | | | | | |
| Sat 12/10/24 | Prestwich Heys v FC St Helens | 0-3 | | | | | |  |
| Wed 16/10/24 | South Liverpool v FC St Helens * | 1-1 | | | | | | |
| Tue 22/10/24 | Padiham v FC St Helens * | 3-3 | | | | | | |
| Fri 01/11/24 | FC St Helens v Chadderton * | 1-0 | | | | | | |
| Tue 05/11/24 | Bury v FC St Helens * | 1-1 | | | | | | |
| Sat 09/11/24 | FC St Helens v Barnoldswick Town * | 0-1 | | | | | | |
| Tue 12/11/24 | FC St Helens v Glossop North End | 1-1 | | | | | | |
| Sat 16/11/24 | Squires Gate v FC St Helens | 2-3 | | | | | | |
| Tue 26/11/24 | FC St Helens v Lower Breck (CUP) | 1-2 | | | | | | |
| Sat 30/11/24 | FC St Helens v Colne | 2-0 | | | | | | |
| Tue 17/12/24 | Glossop North End v FC St Helens | 2-0 | | | | | | |
| Sat 21/12/24 | FC St Helens v Squires Gate * | 5-0 |  | | | | | |
| Thu 26/12/24 | FC St Helens v Pilkington | 2-1 | | | | | | |
| Sat 28/12/24 | FC Isle of Man v FC St Helens | 3-2 | | | | | | |
| Sat 04/01/25 | Litherland REMYCA v FC St Helens | 4-1 | | | | | | |
| Fri 17/01/25 | Chadderton v FC St Helens * | 3-0 | | | | | | |
| Sat 01/02/25 | FC St Helens v Charnock Richard | 4-1 | | | | | | |
| Sat 08/02/25 | Pilkington v FC St Helens | 0-1 | | | | | | |
| Tue 11/02/25 | Barnoldswick Town v FC St Helens | 4-1 | | | | | | |
| Sat 08/03/25 | Lower Breck v FC St Helens | 5-1 | | | | | | |
| Sat 15/03/25 | FC St Helens v Bury | 0-1 | | |  | | | |
| Sat 22/03/25 | Longridge Town v FC St Helens | 0-4 | | | | | | |
| Sat 29/03/25 | Stockport Town v FC St Helens * | 3-1 | | | | | | |
