| Sat 09/08/25 | Cheadle Town v AFC Liverpool * | 2-0 | | | | | | |
| Tue 12/08/25 | AFC Liverpool v FC St Helens | 1-5 | | | |  | | |
| Sat 16/08/25 | Witton Albion v AFC Liverpool (CUP) | 4-1 | | | | | | |
| Mon 25/08/25 | Pilkington v AFC Liverpool | 0-4 | |  | | | | |
| Sat 30/08/25 | AFC Liverpool v City of Liverpool | 3-4 | | | | | | |
| Sat 13/09/25 | Wythenshawe v AFC Liverpool | 3-1 | | | | | | |
| Tue 16/09/25 | AFC Liverpool v FC Isle of Man | 5-1 | | | | | | |
| Wed 24/09/25 | AFC Liverpool v Daisy Hill (CUP) | 2-1 | | | | | | |
| Sat 04/10/25 | Atherton LR v AFC Liverpool | 3-0 | | | | | | |
| Tue 07/10/25 | AFC Liverpool v Runcorn Town (CUP) * | 3-3 | | | | | | |
| Fri 10/10/25 | AFC Liverpool v Maghull (CUP) | 3-1 | | | | | | |
| Tue 14/10/25 | Padiham v AFC Liverpool | 4-0 | | | | | | |
| Sat 18/10/25 | Barnoldswick Town v AFC Liverpool (CUP) | 1-0 | | | | | | |
| Tue 21/10/25 | Charnock Richard v AFC Liverpool | 2-2 | | | | | | |
| Sat 25/10/25 | Chadderton v AFC Liverpool | 0-1 | | | | | | |
| Tue 28/10/25 | AFC Liverpool v South Liverpool | 1-1 | | | | | | |
| Wed 05/11/25 | AFC Liverpool v Prestwich Heys | 1-1 | | | | | | |
| Fri 07/11/25 | City of Liverpool v AFC Liverpool | 1-3 | | | | | | |
| Tue 11/11/25 | Euxton Villa v AFC Liverpool | 0-3 | | | | | | |
| Wed 19/11/25 | Cammell Laird 1907 v AFC Liverpool (CUP) | 1-3 | | | | | | |
| Sat 29/11/25 | AFC Liverpool v Cheadle Town | 2-2 | | | | | |  |
| Sat 06/12/25 | AFC Liverpool v Abbey Hey | 3-0 | | | | | | |
| Wed 10/12/25 | AFC Liverpool v Wythenshawe | 1-5 | | | | | | |
| Sat 13/12/25 | FC Isle of Man v AFC Liverpool | 5-0 | | | | | | |
| Tue 16/12/25 | Glossop North End v AFC Liverpool | 1-1 | | | | | | |
| Sat 27/12/25 | Litherland REMYCA v AFC Liverpool | 1-3 | | | | | | |
| Sat 17/01/26 | Barnoldswick Town v AFC Liverpool | 0-7 | | | | | | |
| Tue 20/01/26 | AFC Liverpool v Stockport Town | 4-0 | | | | | | |
| Sat 24/01/26 | AFC Liverpool v Chadderton | 4-1 | | | | | | |
| Sat 31/01/26 | AFC Liverpool v Glossop North End | 2-2 | | | | | | |
| Tue 10/02/26 | AFC Liverpool v Atherton LR | 1-3 | | | | | | |
| Tue 17/02/26 | AFC Liverpool v Euxton Villa (CUP) | 3-0 | | | | | | |
| Sat 28/02/26 | Irlam v AFC Liverpool | 1-0 | | | | | | |
| Wed 04/03/26 | AFC Liverpool v Padiham | 0-2 | | | | | | |
| Sat 07/03/26 | AFC Liverpool v Barnoldswick Town | 3-1 | | | | | | |
| Tue 10/03/26 | AFC Liverpool v Ramsbottom United | 0-2 | | | | | | |
| Thu 12/03/26 | Abbey Hey v AFC Liverpool | 0-1 | | | | | | |
| Sat 14/03/26 | South Liverpool v AFC Liverpool | 1-1 | | | | | | |
| Wed 18/03/26 | AFC Liverpool v Longridge Town | 2-0 | | | | | | |
| Sat 21/03/26 | AFC Liverpool v Burscough | 2-1 | | | | | | |
| Sat 28/03/26 | AFC Liverpool v West Didsbury & Chorlton | 4-1 | | | | | | |
| Tue 31/03/26 | AFC Liverpool v Euxton Villa | 2-0 | | | | | | |
| Fri 03/04/26 | AFC Liverpool v Nelson (CUP) | 3-1 | | | | | | |
| Mon 06/04/26 | AFC Liverpool v Litherland REMYCA | 3-1 | | | | | | |
| Wed 08/04/26 | Longridge Town v AFC Liverpool | 2-3 | | | | | | |
