| Sat 25/10/25 | South Liverpool v Atherton LR | 2-1 | | | |  | | |
| Tue 28/10/25 | AFC Liverpool v South Liverpool | 1-1 | | | | | | |
| Sat 01/11/25 | Abbey Hey v South Liverpool * | 2-3 | | | | | | |
| Sat 22/11/25 | South Liverpool v Irlam | 0-3 | | | | | | |
| Tue 25/11/25 | Wythenshawe v South Liverpool | 3-1 | | | | | | |
| Sat 29/11/25 | South Liverpool v Chadderton | 2-3 | | | | | | |
| Tue 02/12/25 | FC St Helens v South Liverpool | 3-1 | | | | | | |
| Wed 10/12/25 | Litherland REMYCA v South Liverpool (CUP) | 1-4 | | | | | | |
| Tue 13/01/26 | Burscough v South Liverpool | 5-2 | | | | | | |
| Sat 24/01/26 | FC Isle of Man v South Liverpool | 3-2 | | | | | | |
| Wed 28/01/26 | South Liverpool v Pilkington | 3-1 | | | | | | |
| Sat 31/01/26 | Cheadle Town v South Liverpool | 4-2 | | | | | | |
| Wed 04/02/26 | South Liverpool v Ramsbottom United | 0-2 | | | | | | |
| Sat 07/02/26 | South Liverpool v Longridge Town | 2-2 | | | | | | |
| Tue 10/02/26 | City of Liverpool v South Liverpool | 1-2 | | | | | | |
| Wed 18/02/26 | West Didsbury & Chorlton v South Liverpool | 4-0 | | | | | | |
| Wed 25/02/26 | South Liverpool v Warrington Rylands 1906 (CUP) * | 0-3 | | | | | | |
| Sat 28/02/26 | Stockport Town v South Liverpool * | 1-1 | | | | | | |
| Tue 03/03/26 | Irlam v South Liverpool | 0-2 | |  | | | | |
| Sat 07/03/26 | Padiham v South Liverpool | 1-0 | | | | | | |
| Sat 21/03/26 | South Liverpool v Prestwich Heys | 0-2 | | | | | | |
| Sat 28/03/26 | Charnock Richard v South Liverpool | 4-0 | | | | | | |
| Sat 04/04/26 | Euxton Villa v South Liverpool | 3-0 | | | | | | |
| Mon 06/04/26 | South Liverpool v City of Liverpool | 5-0 | | | | | | |
