| Sat 26/07/25 | Maine Road v Garstang | 1-0 | |  | | | | |
| Sat 06/09/25 | AFC Blackpool v Maine Road | 2-0 | | | | | | |
| Sat 13/09/25 | Maine Road v Thornton Cleveleys * | 3-0 | | | | | | |
| Fri 26/09/25 | Droylsden v Maine Road (CUP) * | 1-2 | | | | | | |
| Sat 11/10/25 | Maine Road v Cheadle Town (CUP) | 1-2 | | | |  | | |
| Sat 18/10/25 | Daisy Hill v Maine Road | 2-2 | | | | | | |
| Sat 25/10/25 | Holker Old Boys v Maine Road | 3-2 | | | | | | |
| Sat 01/11/25 | Maghull v Maine Road | 1-0 | | | | | | |
| Mon 10/11/25 | Maine Road v Ashton Town | 1-3 | | | | | | |
| Sat 22/11/25 | Maine Road v Daisy Hill | 2-4 | | | | | | |
| Sat 29/11/25 | Garstang v Maine Road | 6-1 | | | | | | |
| Sat 13/12/25 | Maine Road v Squires Gate * | 1-4 | | | | | | |
| Fri 26/12/25 | Droylsden v Maine Road * | 2-1 | | | | | | |
| Sat 03/01/26 | Thornton Cleveleys v Maine Road | 5-2 | | | | | | |
| Mon 19/01/26 | Maine Road v AFC Blackpool * | 2-1 | | | | | | |
| Sat 24/01/26 | Darwen FC v Maine Road * | 2-1 | | | | | | |
| Sat 31/01/26 | Nelson v Maine Road (CUP) * | 1-1 | | | | | | |
| Mon 02/02/26 | Maine Road v Fulwood Amateurs | 3-1 | | | | | | |
| Sat 14/02/26 | Maine Road v Colne | 3-3 | | | | | | |
| Tue 17/02/26 | Fulwood Amateurs v Maine Road | 4-2 | | | | | | |
| Sat 21/02/26 | Maine Road v Darwen FC | 0-1 | | | | | | |
| Sat 28/02/26 | Ashton Athletic v Maine Road * | 2-1 | | | | | | |
| Sat 07/03/26 | Maine Road v Holker Old Boys | 1-2 | | | | | | |
| Mon 09/03/26 | Maine Road v Nelson | 4-5 | | | | | | |
| Sat 21/03/26 | Maine Road v Maghull * | 1-2 | | | | | | |
| Sat 28/03/26 | Steeton v Maine Road | 5-2 | | | | | | |
| Wed 01/04/26 | Nelson v Maine Road | 4-0 | | | | | | |
| Sat 04/04/26 | MSB Woolton v Maine Road | 5-2 | | | | | | |
| Mon 06/04/26 | Maine Road v Droylsden | 0-4 | | | | | | |
