| Sat 26/07/25 | Ramsbottom United v Atherton LR | 2-1 | | | | | | |
| Tue 29/07/25 | Atherton LR v South Liverpool * | 1-3 | | | | | | |
| Sat 02/08/25 | Atherton LR v Ossett United (CUP) | 1-0 | |  | | | | |
| Sat 09/08/25 | City of Liverpool v Atherton LR | 0-6 | | | | | | |
| Wed 13/08/25 | West Didsbury & Chorlton v Atherton LR | 0-1 | | | | | | |
| Sat 16/08/25 | FC St Helens v Atherton LR (CUP) | 0-2 | | | | | | |
| Mon 25/08/25 | Atherton LR v Stockport Town | 5-0 | | | | | | |
| Sat 30/08/25 | Atherton LR v Atherton Collieries (CUP) | 5-2 | | | | | | |
| Sat 06/09/25 | Cheadle Town v Atherton LR | 1-3 | | | | | | |
| Sat 20/09/25 | Atherton LR v FC St Helens | 2-1 | | | |  | | |
| Tue 23/09/25 | Longridge Town v Atherton LR | 1-0 | | | | | | |
| Sat 18/10/25 | Atherton LR v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 25/10/25 | South Liverpool v Atherton LR | 2-1 | | | | | | |
| Sat 01/11/25 | Atherton LR v Glossop North End * | 2-3 | | | | | | |
| Tue 04/11/25 | Atherton LR v Longridge Town | 3-2 | | | | | | |
| Sat 08/11/25 | Liversedge v Atherton LR (CUP) | 2-1 | | | | | | |
| Tue 11/11/25 | Atherton LR v Irlam | - | | | | | | |
| Sat 22/11/25 | Abbey Hey v Atherton LR | 1-2 | | | | | | |
| Tue 25/11/25 | Atherton LR v Irlam | 1-4 | | | | | | |
| Sat 06/12/25 | Atherton LR v Barnoldswick Town * | 2-0 | | | | | | |
| Sat 13/12/25 | Pilkington v Atherton LR | 0-1 | | | | | | |
| Sat 20/12/25 | Euxton Villa v Atherton LR | - | | | | | | |
| Fri 26/12/25 | Atherton LR v Burscough | 1-0 | | | | | | |
| Sat 17/01/26 | Prestwich Heys v Atherton LR | 0-0 | | | | | | |
| Tue 20/01/26 | Atherton LR v Prestwich Heys | 2-1 |  | | | | | |
| Wed 28/01/26 | Atherton LR v FC Isle of Man | 3-1 | | | | | | |
| Sat 31/01/26 | Padiham v Atherton LR * | 2-3 | | | | | | |
| Tue 10/02/26 | AFC Liverpool v Atherton LR | 1-3 | | | | | | |
| Tue 17/02/26 | Barnoldswick Town v Atherton LR * | 1-3 | | | | | | |
| Sat 21/02/26 | FC St Helens v Atherton LR | - | | | | | | |
| Sun 01/03/26 | Atherton LR v Euxton Villa | 2-0 | | | | | | |
| Sat 07/03/26 | FC Isle of Man v Atherton LR | 1-5 | | | | | | |
| Tue 10/03/26 | Atherton LR v City of Liverpool * | 3-0 | | | | | | |
| Sat 14/03/26 | Atherton LR v Pilkington | 4-0 | | | | | | |
| Tue 17/03/26 | Wythenshawe v Atherton LR | 3-3 | | | | | | |
| Sat 21/03/26 | Stockport Town v Atherton LR | 1-3 | | | | | | |
| Tue 24/03/26 | Euxton Villa v Atherton LR | 0-5 | | | | | |  |
| Sat 28/03/26 | Chadderton v Atherton LR | 0-3 | | | | | | |
| Tue 31/03/26 | FC St Helens v Atherton LR | 1-3 | | | | | | |
| Sat 04/04/26 | Atherton LR v Charnock Richard | 1-2 | | | | | | |
| Mon 06/04/26 | Burscough v Atherton LR * | 0-2 | | | | | | |
