| Mon 25/08/25 | City of Liverpool v West Didsbury & Chorlton * | 1-4 | | | | | | |
| Sat 30/08/25 | West Didsbury & Chorlton v Runcorn Linnets (CUP) * | 0-2 | | | | | | |
| Sat 13/09/25 | West Didsbury & Chorlton v Barnoldswick Town * | 4-0 | |  | | | | |
| Sat 27/09/25 | West Didsbury & Chorlton v Cheadle Heath Nomads (CUP) | 4-0 | | | | | | |
| Wed 01/10/25 | West Didsbury & Chorlton v AFC Liverpool * | 4-3 | | | | | | |
| Sat 11/10/25 | West Didsbury & Chorlton v Abbey Hey (CUP) | 4-0 | | | | | | |
| Sat 01/11/25 | Pilkington v West Didsbury & Chorlton * | 0-5 | | | | | | |
| Wed 12/11/25 | West Didsbury & Chorlton v City of Liverpool * | 6-1 | | | | | | |
| Sat 22/11/25 | Ramsbottom United v West Didsbury & Chorlton (CUP) | 1-2 | | | | | | |
| Wed 26/11/25 | West Didsbury & Chorlton v Stalybridge Celtic (CUP) | 3-1 | | | | | | |
| Sat 29/11/25 | West Didsbury & Chorlton v Charnock Richard | - | | | | | | |
| Wed 03/12/25 | West Didsbury & Chorlton v Stockport Town * | 1-3 | | | | | | |
| Sat 06/12/25 | Rossington Main v West Didsbury & Chorlton (CUP) | 0-3 | | | | | | |
| Fri 12/12/25 | Abbey Hey v West Didsbury & Chorlton | 1-2 | | | | | | |
| Sat 10/01/26 | FC St Helens v West Didsbury & Chorlton | - | | | | | | |
| Wed 14/01/26 | West Didsbury & Chorlton v Charnock Richard | 1-4 | | | | | | |
| Sat 17/01/26 | West Didsbury & Chorlton v Nelson (CUP) | 1-0 | | | | | | |
| Wed 21/01/26 | West Didsbury & Chorlton v FC Isle of Man | 3-2 | | | | | | |
| Sat 24/01/26 | Stockport Town v West Didsbury & Chorlton | 1-0 | | | | | | |
| Wed 28/01/26 | West Didsbury & Chorlton v Abbey Hey | 3-1 | | | | | | |
| Wed 04/02/26 | West Didsbury & Chorlton v Chadderton | 2-3 | | | | | | |
| Tue 10/02/26 | Padiham v West Didsbury & Chorlton * | 1-2 | | | | | | |
| Wed 18/02/26 | West Didsbury & Chorlton v South Liverpool | 4-0 | | | | | | |
| Sat 21/02/26 | West Didsbury & Chorlton v Ramsbottom United | - | | | | | | |
