| Sat 27/09/25 | Bacup Borough v AFC Blackpool (CUP) * | 0-0 | |  | | | | |
| Sat 11/10/25 | AFC Blackpool v Barnoldswick Town (CUP) * | 3-0 | | | | | | |
| Sat 25/10/25 | AFC Blackpool v MSB Woolton * | 2-1 | | | | | | |
| Tue 28/10/25 | Droylsden v AFC Blackpool (CUP) | 1-3 |  | | | | | |
| Sat 01/11/25 | AFC Blackpool v Steeton * | 1-0 | | | | | | |
| Sat 08/11/25 | AFC Blackpool v Ashton Athletic * | 2-0 | | | | | | |
| Tue 11/11/25 | Colne v AFC Blackpool | - | | | | | | |
| Sat 15/11/25 | Maine Road v AFC Blackpool (CUP) | 0-0 | | | | | | |
| Sat 22/11/25 | Burscough v AFC Blackpool (CUP) | 3-1 | | | | | | |
| Sat 29/11/25 | AFC Blackpool v Colne | 2-2 | | | | | | |
| Mon 01/12/25 | Daisy Hill v AFC Blackpool | - | | | | | | |
| Sat 13/12/25 | AFC Blackpool v Thornton Cleveleys * | 2-2 | | | | | | |
| Sat 10/01/26 | Maghull v AFC Blackpool * | 2-2 | | | | | | |
| Mon 19/01/26 | Maine Road v AFC Blackpool * | 2-1 | | | | | | |
| Sat 24/01/26 | Fulwood Amateurs v AFC Blackpool | 4-0 | | | | | | |
| Tue 27/01/26 | Colne v AFC Blackpool | 5-1 | | | | | | |
| Sat 31/01/26 | Steeton v AFC Blackpool * | 3-1 | | | | | | |
| Mon 02/02/26 | Daisy Hill v AFC Blackpool | 4-1 | | | | | | |
| Sat 07/02/26 | AFC Blackpool v Daisy Hill * | 2-4 | | | | | | |
| Wed 18/02/26 | AFC Blackpool v Droylsden * | 0-2 | | | | | | |
| Sat 28/02/26 | AFC Blackpool v Holker Old Boys * | 3-0 | | | | | | |
| Wed 04/03/26 | Garstang v AFC Blackpool * | 3-0 | | | | | | |
| Sat 07/03/26 | Ashton Town v AFC Blackpool | 1-0 | | | | | | |
| Tue 10/03/26 | Thornton Cleveleys v AFC Blackpool * | 3-2 | | | | | | |
| Sat 21/03/26 | AFC Blackpool v Darwen FC * | 1-2 | | | | | | |
| Sat 28/03/26 | Bacup Borough v AFC Blackpool * | 0-1 | | | | | | |
| Mon 06/04/26 | AFC Blackpool v Squires Gate * | 0-1 | | | | | | |
| Sat 11/04/26 | MSB Woolton v AFC Blackpool | 3-1 | | | | | | |
