| Sat 26/07/25 | Burscough v Abbey Hey | 1-1 | | | | | | |
| Tue 29/07/25 | Burscough v AFC Liverpool | 1-1 | | | | | | |
| Sat 02/08/25 | Charnock Richard v Burscough (CUP) | 1-0 | | | | | | |
| Fri 08/08/25 | Prestwich Heys v Burscough | 0-2 | |  | | | | |
| Tue 12/08/25 | Burscough v Longridge Town | 2-1 | | | | | | |
| Sat 16/08/25 | Burscough v Litherland REMYCA | 3-0 |  | | | | | |
| Sat 23/08/25 | Burscough v MSB Woolton (CUP) | 4-2 | | | |  | | |
| Mon 25/08/25 | South Liverpool v Burscough | 0-3 | | | | | | |
| Sat 30/08/25 | Burscough v FC St Helens | 1-2 | | | | | | |
| Sat 06/09/25 | Burscough v FC Isle of Man | 5-0 | | | | | | |
| Tue 09/09/25 | Euxton Villa v Burscough | 0-1 | | | | | | |
| Sat 13/09/25 | Burscough v Cheadle Town | 0-1 | | | | | | |
| Tue 16/09/25 | Ramsbottom United v Burscough | 2-0 | | | | | | |
| Sat 20/09/25 | Sheffield v Burscough (CUP) | 2-2 | | | | | | |
| Tue 23/09/25 | Padiham v Burscough | 3-0 | | | | | | |
| Sat 27/09/25 | Daisy Hill v Burscough (CUP) * | 0-0 | | | | | | |
| Sat 04/10/25 | Burscough v City of Liverpool | 2-1 | | | | | | |
| Tue 07/10/25 | Burscough v Pilkington | 3-1 | | | | | | |
| Sat 11/10/25 | Atherton LR v Burscough (CUP) | 1-1 | | | | | | |
| Tue 14/10/25 | Burscough v Ashton Town (CUP) | 3-1 | | | | | | |
| Sat 18/10/25 | Burscough v Billingham Synthonia (CUP) | 6-0 | | | | | | |
| Tue 21/10/25 | Burscough v Euxton Villa | 3-0 | | | | | | |
| Sat 25/10/25 | West Didsbury & Chorlton v Burscough | 3-1 | | | | | | |
| Tue 28/10/25 | Chadderton v Burscough | 1-0 | | | | | | |
| Sat 01/11/25 | Barnoldswick Town v Burscough | 1-2 | | | | | | |
| Sat 08/11/25 | Burscough v Ashton Town (CUP) | 3-1 | | | | | | |
| Sat 15/11/25 | Burscough v Glossop North End | 1-2 | | | | | | |
| Sat 22/11/25 | Burscough v AFC Blackpool (CUP) | 3-1 | | | | | | |
