| Tue 23/09/25 | Prestwich Heys v Charnock Richard | 3-3 |  | | | | | |
| Sat 27/09/25 | Stockport Town v Prestwich Heys (CUP) | 2-3 | | | |  | | |
| Tue 07/10/25 | FC St Helens v Prestwich Heys | 0-2 | |  | | | | |
| Sat 11/10/25 | Ramsbottom United v Prestwich Heys (CUP) | 3-2 | | | | | | |
| Tue 14/10/25 | Prestwich Heys v Pilkington | 2-0 | | | | | | |
| Tue 21/10/25 | Abbey Hey v Prestwich Heys | 2-1 | | | | | | |
| Sat 25/10/25 | Padiham v Prestwich Heys | 0-2 | | | | | | |
| Tue 28/10/25 | Ramsbottom United v Prestwich Heys | 3-0 | | | | | | |
| Sat 01/11/25 | Prestwich Heys v Ramsbottom United | 0-3 | | | | | | |
| Sat 22/11/25 | Prestwich Heys v Glossop North End | 0-2 | | | | | | |
| Tue 16/12/25 | Prestwich Heys v Abbey Hey | 6-0 | | | | | | |
| Sat 20/12/25 | Prestwich Heys v Barnoldswick Town | 0-2 | | | | | | |
| Fri 26/12/25 | Chadderton v Prestwich Heys | 1-2 | | | | | | |
| Wed 14/01/26 | Pilkington v Prestwich Heys | 0-1 | | | | | |  |
| Sat 17/01/26 | Prestwich Heys v Atherton LR | 0-0 | | | | | | |
| Tue 20/01/26 | Atherton LR v Prestwich Heys | 2-1 | | | | | | |
| Sat 24/01/26 | Burscough v Prestwich Heys | 1-1 | | | | | | |
| Sat 31/01/26 | Wythenshawe v Prestwich Heys | 1-1 | | | | | | |
| Tue 03/02/26 | Prestwich Heys v Wythenshawe | 1-2 | | | | | | |
| Tue 10/02/26 | Prestwich Heys v Euxton Villa | 3-1 | | | | | | |
| Sat 14/02/26 | Longridge Town v Prestwich Heys | 1-1 | | | | | | |
| Tue 17/02/26 | City of Liverpool v Prestwich Heys * | 0-7 | | | | | | |
| Sat 21/02/26 | Prestwich Heys v Stockport Town | - | | | | | | |
| Sat 28/02/26 | Charnock Richard v Prestwich Heys | 1-2 | | | | | | |
| Tue 03/03/26 | Prestwich Heys v Stockport Town | 1-0 | | | | | | |
| Sat 07/03/26 | Prestwich Heys v Litherland REMYCA | 2-1 | | | | | | |
| Sat 14/03/26 | Prestwich Heys v City of Liverpool | 7-0 | | | | | | |
| Tue 17/03/26 | Prestwich Heys v Irlam | 2-0 | | | | | | |
| Sat 21/03/26 | South Liverpool v Prestwich Heys | - | | | | | | |
