| Sat 26/07/25 | Padiham v Wythenshawe | 3-0 | |  | | | | |
| Tue 29/07/25 | Prestwich Heys v Padiham | 0-2 | | | | | | |
| Sat 02/08/25 | Penistone Church v Padiham (CUP) | 1-4 | | | | | | |
| Sat 09/08/25 | Stockport Town v Padiham | 1-2 | | | | | | |
| Tue 12/08/25 | Padiham v Euxton Villa | 2-0 | | | | | | |
| Sat 16/08/25 | Congleton Town v Padiham (CUP) | 3-0 | | | | | | |
| Sat 23/08/25 | Padiham v Sunderland RCA (CUP) | 2-2 | | | | | | |
| Mon 25/08/25 | Padiham v Ramsbottom United | 3-1 | | | |  | | |
| Sat 30/08/25 | FC Isle of Man v Padiham | 2-3 |  | | | | | |
| Sat 06/09/25 | Abbey Hey v Padiham | 1-2 | | | | | | |
| Sun 21/09/25 | Campion v Padiham (CUP) | 3-1 | | | | | | |
| Tue 23/09/25 | Padiham v Burscough | 3-0 | | | | | | |
| Tue 07/10/25 | Padiham v Longridge Town | 4-1 | | | | | | |
| Tue 14/10/25 | Padiham v AFC Liverpool | 4-0 | | | | | | |
| Sat 18/10/25 | Padiham v Litherland REMYCA | 4-0 | | | | | | |
| Tue 21/10/25 | Chadderton v Padiham | 2-3 | | | | | | |
| Sat 25/10/25 | Padiham v Prestwich Heys | 0-2 | | | | | | |
| Wed 29/10/25 | Litherland REMYCA v Padiham | 2-3 | | | | | | |
| Sat 01/11/25 | Irlam v Padiham | 2-0 | | | | | | |
| Tue 04/11/25 | Padiham v Abbey Hey | 4-1 | | | | | | |
| Sat 08/11/25 | FC St Helens v Padiham | 1-1 | | | | | | |
| Tue 11/11/25 | Padiham v Charnock Richard | - | | | | |  | |
| Tue 20/01/26 | Wythenshawe v Padiham | 6-2 | | | | | | |
| Sat 24/01/26 | Glossop North End v Padiham | 3-1 | | | | | |  |
| Sat 31/01/26 | Padiham v Atherton LR | 2-3 | | | | | | |
| Tue 03/02/26 | Atherton LR v Padiham | 2-1 | | | | | | |
| Sat 07/02/26 | Padiham v Chadderton | 3-3 | | | | | | |
| Tue 10/02/26 | Padiham v West Didsbury & Chorlton | 1-2 | | | | | | |
| Tue 31/03/26 | Longridge Town v Padiham | 0-2 | | | | | | |
| Sat 04/04/26 | Padiham v Pilkington | 4-1 | | | | | | |
| Mon 06/04/26 | Barnoldswick Town v Padiham | 2-1 | | | | | | |
