| Sat 26/07/25 | Euxton Villa v Prestwich Heys * | 1-1 | | | | | | |
| Sat 09/08/25 | West Didsbury & Chorlton v Euxton Villa | 3-3 | | | | | | |
| Tue 12/08/25 | Padiham v Euxton Villa * | 2-0 | | | |  | | |
| Sat 16/08/25 | Euxton Villa v Barnoldswick Town | 2-3 |  | | | | | |
| Sat 23/08/25 | Euxton Villa v Worsbrough Bridge Athletic (CUP) | 2-1 | | | | | | |
| Mon 25/08/25 | Euxton Villa v Litherland REMYCA | 3-2 | | | | | | |
| Sat 30/08/25 | Stockport Town v Euxton Villa | 1-1 | | | | | | |
| Fri 05/09/25 | Euxton Villa v FC St Helens | 1-2 | | | | | | |
| Tue 09/09/25 | Euxton Villa v Burscough * | 0-1 | | | | | | |
| Sat 13/09/25 | Euxton Villa v Irlam | 2-1 | | | | | | |
| Tue 16/09/25 | Chadderton v Euxton Villa | 2-2 | | | | | | |
| Sat 20/09/25 | Euxton Villa v Sandbach United (CUP) * | 3-3 | | | | | | |
| Tue 23/09/25 | Euxton Villa v Ramsbottom United * | 0-4 | | | | | | |
| Fri 26/09/25 | Euxton Villa v Holker Old Boys (CUP) | 5-0 | |  | | | | |
| Sat 04/10/25 | Abbey Hey v Euxton Villa | 1-2 | | | | | | |
| Sat 11/10/25 | Colne v Euxton Villa (CUP) | 1-3 | | | | | | |
| Wed 15/10/25 | South Liverpool v Euxton Villa * | 1-1 | | | | | | |
| Sat 18/10/25 | Euxton Villa v Carlisle City (CUP) | 1-1 | | | | | | |
| Tue 21/10/25 | Burscough v Euxton Villa * | 3-0 | | | | | | |
| Sat 25/10/25 | Euxton Villa v Cheadle Town | 1-1 | | | | | | |
| Sat 01/11/25 | City of Liverpool v Euxton Villa | 0-0 | | | | | | |
| Sat 08/11/25 | Longridge Town v Euxton Villa * | 4-3 | | | | | | |
| Tue 11/11/25 | Euxton Villa v AFC Liverpool * | 0-3 | | | | | | |
| Sat 15/11/25 | Wythenshawe v Euxton Villa | 2-0 | | | | | | |
| Fri 21/11/25 | Euxton Villa v Charnock Richard (CUP) * | 3-3 | | | | | | |
| Sat 29/11/25 | Euxton Villa v Glossop North End * | 3-2 | | | | | | |
| Wed 21/01/26 | Pilkington v Euxton Villa * | 0-3 | | | | | | |
| Sat 24/01/26 | Euxton Villa v Pilkington * | 1-1 | | | | | | |
| Sat 07/02/26 | FC Isle of Man v Euxton Villa * | 1-0 | | | | | | |
| Tue 10/02/26 | Prestwich Heys v Euxton Villa | 3-1 | | | | | | |
| Tue 17/02/26 | AFC Liverpool v Euxton Villa (CUP) * | 3-0 | | | | | | |
| Sat 21/02/26 | Euxton Villa v City of Liverpool * | 4-0 | | | | | | |
