| Sat 31/08/24 | FC St Helens v Stockport Town * | 4-1 | | | | | | |
| Tue 03/09/24 | AFC Liverpool v FC St Helens * | 1-2 | | | | | | |
| Sat 07/09/24 | FC St Helens v Litherland REMYCA * | 2-1 | | | | | | |
| Sat 14/09/24 | Charnock Richard v FC St Helens * | 2-2 | | | | | | |
| Sat 21/09/24 | Stockport Town v FC St Helens (CUP) | 2-1 | | | | | | |
| Sat 05/10/24 | FC St Helens v AFC Liverpool * | 3-2 | | | | | | |
| Tue 08/10/24 | FC St Helens v Litherland REMYCA (CUP) * | 2-1 |  | | | | | |
| Sat 12/10/24 | Prestwich Heys v FC St Helens | 0-3 | |  | | | | |
| Wed 16/10/24 | South Liverpool v FC St Helens | 1-1 | | | |  | | |
| Tue 22/10/24 | Padiham v FC St Helens * | 3-3 | | | | | | |
| Tue 12/11/24 | FC St Helens v Glossop North End * | 1-1 | | | | | | |
| Sat 16/11/24 | Squires Gate v FC St Helens | 2-3 | | | | | |  |
| Thu 26/12/24 | FC St Helens v Pilkington * | 2-1 | | | | | | |
| Sat 28/12/24 | FC Isle of Man v FC St Helens | 3-2 | | | | | | |
| Sat 04/01/25 | Litherland REMYCA v FC St Helens | 4-1 | | | | | | |
| Fri 17/01/25 | Chadderton v FC St Helens * | 3-0 | | | | | | |
| Sat 25/01/25 | Colne v FC St Helens * | 2-1 | | | | | | |
| Sat 01/02/25 | FC St Helens v Charnock Richard * | 4-1 | | | | | | |
| Sat 08/02/25 | Pilkington v FC St Helens * | 0-1 | | | | | | |
| Sat 15/02/25 | FC St Helens v Cheadle Town * | 0-1 | | | | | | |
| Tue 18/02/25 | FC St Helens v Longridge Town * | 3-0 | | | | | | |
| Sat 22/02/25 | FC St Helens v Padiham * | 2-3 | | | | | | |
| Fri 28/02/25 | Ramsbottom United v FC St Helens * | 2-3 | | | | | | |
| Sat 08/03/25 | Lower Breck v FC St Helens * | 5-1 | | | | | | |
| Sat 15/03/25 | FC St Helens v Bury | 0-1 | | | | | | |
| Sat 22/03/25 | Longridge Town v FC St Helens | 0-4 | | | | | | |
| Sat 29/03/25 | Stockport Town v FC St Helens | 3-1 | | | | | | |
