| Sat 26/07/25 | AFC Liverpool v Irlam | 2-3 | | | |  | | |
| Tue 29/07/25 | Irlam v Pilkington | 1-2 | | | | | | |
| Sat 02/08/25 | Irlam v Thackley (CUP) | 4-0 | |  | | | | |
| Sat 09/08/25 | Charnock Richard v Irlam | 3-5 |  | | | | | |
| Tue 12/08/25 | Irlam v FC Isle of Man | 4-0 | | | | | | |
| Sat 16/08/25 | Irlam v Chadderton (CUP) | 0-1 | | | | | | |
| Mon 25/08/25 | Cheadle Town v Irlam | 1-2 | | | | | | |
| Sat 30/08/25 | Litherland REMYCA v Irlam | 0-3 | | | | | | |
| Sat 06/09/25 | Irlam v Prestwich Heys | 2-1 | | | | | | |
| Sat 13/09/25 | Euxton Villa v Irlam * | 2-1 | | | | | | |
| Tue 16/09/25 | Irlam v West Didsbury & Chorlton | 2-4 | | | | | | |
| Sat 20/09/25 | Irlam v Bacup Borough (CUP) * | 2-0 | | | | | | |
| Tue 23/09/25 | Irlam v Wythenshawe | 0-2 | | | | | | |
| Sat 27/09/25 | Irlam v Ramsbottom United | 3-2 | | | | | | |
| Tue 30/09/25 | Irlam v Chadderton (CUP) * | 0-3 | | | | | | |
| Sat 04/10/25 | Stockport Town v Irlam | 0-3 | | | | | | |
| Tue 07/10/25 | Irlam v Atherton LR | 3-0 | | | | | | |
| Tue 14/10/25 | FC St Helens v Irlam | 2-2 | | | | | | |
| Sat 18/10/25 | Irlam v Shildon (CUP) | 2-2 | | | | | | |
| Sat 25/10/25 | Longridge Town v Irlam | 5-1 | | | | | | |
| Wed 29/10/25 | West Didsbury & Chorlton v Irlam | 2-5 | | | | | | |
| Sat 01/11/25 | Irlam v Padiham | 2-0 | | | | | | |
| Sat 08/11/25 | Prestwich Heys v Irlam (CUP) | 0-0 | | | | | | |
| Tue 11/11/25 | Atherton LR v Irlam | - | | | | | | |
| Tue 18/11/25 | Radcliffe v Irlam (CUP) | 5-2 | | | | | | |
| Sat 22/11/25 | South Liverpool v Irlam | 0-3 | | | | | | |
| Tue 25/11/25 | Atherton LR v Irlam | 1-4 | | | | | | |
| Tue 02/12/25 | Irlam v Chadderton | 2-4 | | | | | | |
| Sat 06/12/25 | FC Isle of Man v Irlam | 2-2 | | | | | | |
| Sat 13/12/25 | Irlam v FC St Helens | 4-1 | | | | | | |
| Sat 20/12/25 | Burscough v Irlam | 3-0 | | | | | | |
| Fri 26/12/25 | Irlam v Glossop North End | 0-1 | | | | | | |
