| Sat 10/01/26 | FC St Helens v West Didsbury & Chorlton | - | |  | | | | |
| Wed 14/01/26 | West Didsbury & Chorlton v Charnock Richard | 1-4 |  | | | | | |
| Sat 17/01/26 | West Didsbury & Chorlton v Nelson (CUP) | 1-0 | | | | | | |
| Wed 21/01/26 | West Didsbury & Chorlton v FC Isle of Man | 3-2 | | | | | | |
| Sat 24/01/26 | Stockport Town v West Didsbury & Chorlton | 1-0 | | | | | | |
| Wed 28/01/26 | West Didsbury & Chorlton v Abbey Hey | 3-1 | | | |  | | |
| Sat 31/01/26 | Burscough v West Didsbury & Chorlton | 1-0 | | | | | | |
| Wed 04/02/26 | West Didsbury & Chorlton v Chadderton * | 2-3 | | | | | | |
| Tue 10/02/26 | Padiham v West Didsbury & Chorlton | 1-2 | | | | | | |
| Sat 14/02/26 | West Didsbury & Chorlton v Winsford United (CUP) | 4-1 | | | | | | |
| Wed 18/02/26 | West Didsbury & Chorlton v South Liverpool | 4-0 | | | | | | |
| Sat 21/02/26 | West Didsbury & Chorlton v Ramsbottom United | - | | | | | | |
| Tue 24/02/26 | FC St Helens v West Didsbury & Chorlton | 3-0 | | | | | | |
| Sat 28/02/26 | Hallen v West Didsbury & Chorlton (CUP) | 1-1 | | | | | | |
| Tue 03/03/26 | Droylsden v West Didsbury & Chorlton (CUP) * | 4-0 | | | | | | |
| Thu 05/03/26 | West Didsbury & Chorlton v Thornton Cleveleys (CUP) * | 1-1 | | | | | | |
| Sat 07/03/26 | West Didsbury & Chorlton v FC St Helens | 1-1 | | | | | | |
| Wed 11/03/26 | Litherland REMYCA v West Didsbury & Chorlton * | 1-1 | | | | | | |
| Sat 14/03/26 | Longridge Town v West Didsbury & Chorlton | 0-4 | | | | | | |
| Tue 17/03/26 | Ramsbottom United v West Didsbury & Chorlton | 3-1 | | | | | |  |
| Sat 21/03/26 | West Didsbury & Chorlton v Padiham | 1-2 | | | | | | |
| Sat 28/03/26 | AFC Liverpool v West Didsbury & Chorlton | 4-1 | | | | | | |
| Wed 01/04/26 | West Didsbury & Chorlton v Thornton Cleveleys (CUP) * | 4-1 | | | | | | |
| Sat 04/04/26 | Burscough v West Didsbury & Chorlton (CUP) | 0-0 | | | | | | |
| Sat 11/04/26 | West Didsbury & Chorlton v Prestwich Heys * | 5-2 | | | | | | |
| Mon 13/04/26 | West Didsbury & Chorlton v Cheadle Town | 1-2 | | | | | | |
| Wed 15/04/26 | West Didsbury & Chorlton v Ramsbottom United | 1-3 | | | | | | |
