| Sat 02/08/25 | Bury v South Liverpool (CUP) * | 6-0 | | | | | | |
| Sat 09/08/25 | Chadderton v South Liverpool | 7-2 | | | | | | |
| Wed 13/08/25 | South Liverpool v Litherland REMYCA | 2-1 | | | | | | |
| Sat 16/08/25 | Pilkington v South Liverpool | 1-6 | | | | | | |
| Mon 25/08/25 | South Liverpool v Burscough | 0-3 | | | | | | |
| Sat 30/08/25 | Glossop North End v South Liverpool | 0-1 | |  | | | | |
| Sat 06/09/25 | South Liverpool v West Didsbury & Chorlton | 0-1 | | | | | | |
| Wed 17/09/25 | South Liverpool v Abbey Hey | 5-3 |  | | | | | |
| Sat 20/09/25 | Litherland REMYCA v South Liverpool | 0-3 | | | | | | |
| Wed 08/10/25 | South Liverpool v FC Isle of Man | 3-1 | | | |  | | |
| Sat 11/10/25 | Longridge Town v South Liverpool | 1-1 | | | | | |  |
| Wed 15/10/25 | South Liverpool v Euxton Villa | 1-1 | | | | | | |
| Sat 18/10/25 | Northallerton Town v South Liverpool (CUP) | 1-2 | | | | | | |
| Sat 25/10/25 | South Liverpool v Atherton LR | 2-1 | | | | | | |
| Tue 28/10/25 | AFC Liverpool v South Liverpool | 1-1 | | | | | | |
| Sat 01/11/25 | Abbey Hey v South Liverpool | 2-3 | | | | | | |
| Wed 05/11/25 | South Liverpool v Charnock Richard | 3-0 | | | | | | |
| Sat 08/11/25 | South Liverpool v Barton Town (CUP) | 4-0 | | | | | | |
| Tue 25/11/25 | Wythenshawe v South Liverpool | 3-1 | | | | | | |
| Sat 29/11/25 | South Liverpool v Chadderton | 2-3 | | | | | | |
| Tue 02/12/25 | FC St Helens v South Liverpool | 3-1 | | | | | | |
| Sat 06/12/25 | Albion Sports v South Liverpool (CUP) | 0-3 | | | | | | |
| Sat 13/12/25 | Barnoldswick Town v South Liverpool | 0-0 | | | | | | |
| Wed 17/12/25 | South Liverpool v Cheadle Town | 2-2 | | | | | | |
| Sat 20/12/25 | South Liverpool v Padiham | 1-0 | | | | | | |
| Sat 03/01/26 | South Liverpool v Wythenshawe | 1-3 | | | | | | |
