| Sat 26/07/25 | South Liverpool v Stockport Town * | 0-3 | | | | | | |
| Tue 29/07/25 | Atherton LR v South Liverpool | 1-3 |  | | | | | |
| Sat 02/08/25 | Bury v South Liverpool (CUP) | 6-0 | | | | | | |
| Sat 09/08/25 | Chadderton v South Liverpool | 7-2 | | | | | | |
| Wed 13/08/25 | South Liverpool v Litherland REMYCA | 2-1 | | | | | | |
| Sat 16/08/25 | Pilkington v South Liverpool | 1-6 | | | | | | |
| Mon 25/08/25 | South Liverpool v Burscough | 0-3 | | | | | | |
| Sat 30/08/25 | Glossop North End v South Liverpool | 0-1 | |  | | | | |
| Sat 06/09/25 | South Liverpool v West Didsbury & Chorlton | 0-1 | | | | | | |
| Wed 10/09/25 | South Liverpool v FC St Helens * | 1-2 | | | | | | |
| Sat 13/09/25 | Prestwich Heys v South Liverpool * | 3-0 | | | | | | |
| Wed 17/09/25 | South Liverpool v Abbey Hey | 5-3 | | | | | | |
| Sat 20/09/25 | Litherland REMYCA v South Liverpool | 0-3 | | | | | | |
| Sat 27/09/25 | AFC Liverpool v South Liverpool (CUP) | 3-1 | | | | | | |
| Sat 01/11/25 | Abbey Hey v South Liverpool * | 2-3 | | | | | | |
| Wed 05/11/25 | South Liverpool v Charnock Richard | 3-0 | | | | | | |
| Sat 17/01/26 | South Liverpool v Winsford United (CUP) * | 2-5 | | | | | | |
| Sat 24/01/26 | FC Isle of Man v South Liverpool * | 3-2 | | | | | | |
| Wed 28/01/26 | South Liverpool v Pilkington | 3-1 | | | | | | |
| Sat 31/01/26 | Cheadle Town v South Liverpool | 4-2 | | | | | |  |
| Sat 07/02/26 | South Liverpool v Longridge Town | 2-2 | | | | | | |
| Tue 10/02/26 | City of Liverpool v South Liverpool | 1-2 | | | | | | |
| Sat 21/03/26 | South Liverpool v Prestwich Heys * | 0-2 | | | | | | |
| Sat 28/03/26 | Charnock Richard v South Liverpool * | 4-0 | | | | | | |
| Sat 04/04/26 | Euxton Villa v South Liverpool | 3-0 | | | | | | |
| Mon 06/04/26 | South Liverpool v City of Liverpool | 5-0 | | | | | | |
